ENSMUSG00000004070


Mus musculus

Features
Gene ID: ENSMUSG00000004070
  
Biological name :Hmox2
  
Synonyms : Hmox2 / Mus musculus heme oxygenase 2 (Hmox2), transcript variant 3, mRNA. / O70252
  
Possible biological names infered from orthology : heme oxygenase 2 / P30519
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A1
Gene start: 4726361
Gene end: 4766742
  
Corresponding Affymetrix probe sets: 10433292 (MoGene1.0st)   1416399_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115932
Ensembl peptide - ENSMUSP00000112397
Ensembl peptide - ENSMUSP00000122699
Ensembl peptide - ENSMUSP00000113110
Ensembl peptide - ENSMUSP00000004172
Ensembl peptide - ENSMUSP00000112378
NCBI entrez gene - 15369     See in Manteia.
MGI - MGI:109373
RefSeq - NM_010443
RefSeq - XM_006521804
RefSeq - XM_006521803
RefSeq - NM_001136066
RefSeq - NM_001357050
RefSeq Peptide - NP_001129538
RefSeq Peptide - NP_001343979
RefSeq Peptide - NP_034573
swissprot - D3YXN4
swissprot - O70252
swissprot - Q544R7
swissprot - D3Z4A2
swissprot - D3YX62
Ensembl - ENSMUSG00000004070
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmox2aENSDARG00000114695Danio rerio
 hmox2bENSDARG00000078452Danio rerio
 HMOX2ENSGALG00000007638Gallus gallus
 HMOX2ENSG00000103415Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hmox1 / P14901 / Heme oxygenase 1 / P09601*ENSMUSG0000000541343


Protein motifs (from Interpro)
Interpro ID Name
 IPR002051  Haem oxygenase
 IPR016053  Haem oxygenase-like
 IPR016084  Haem oxygenase-like, multi-helical
 IPR018207  Haem oxygenase conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia ISO
 biological_processGO:0006788 heme oxidation IEA
 biological_processGO:0006979 response to oxidative stress IBA
 biological_processGO:0042167 heme catabolic process IBA
 biological_processGO:0055072 iron ion homeostasis IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IBA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004392 heme oxygenase (decyclizing) activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Heme degradation
Neutrophil degranulation
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0001770 abnormal iron level "anomalous concentrations of this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Tg(SOD1)76Dpr/0
Genetic Background: involves: 129S4/SvJae * C3H/HeJ * C57BL/6 * C57BL/6J

Allelic Composition: Hmox2tm1Poss/Hmox2tm1Poss,Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

 MP:0002309 abnormal vital capacity "anomaly in the amount of air that is exhaled by a maximal expiration following a maximal inspiration" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

 MP:0002726 abnormal pulmonary vein morphology "structrual anomaly of the veins that return oxygenated blood from the lungs to the left atrium of the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

 MP:0003477 abnormal nerve fiber response "anomaly in the electrophysiological recordings from a single or several nerve fiber(s)" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

 MP:0004036 abnormal muscle relaxation "altered ability of the muscle to lengthen following contractions" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Tg(SOD1)76Dpr/0
Genetic Background: involves: 129S4/SvJae * C3H/HeJ * C57BL/6 * C57BL/6J

Allelic Composition: Hmox2tm1Poss/Hmox2tm1Poss,Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

 MP:0005574 decreased breathing frequency "fewer than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

 MP:0006001 abnormal intestinal transit time "increase or decrease in the time it takes for a bolus of material to pass through the intestine" [smb:Susan M Bello, Mouse Genome Iformatics Curator]
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Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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