MP:0000609 | abnormal liver physiology | "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Agrp-cre)1Gsb/0 Genetic Background: involves: 129 * FVB/N
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MP:0001260 | increased body weight | "greater than normal average weight " [J:33400] |
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Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Slc17a6tm1.1Thna/Slc17a6tm1.1Thna Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Agrptm1(cre)Lowl/Agrp+ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
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MP:0001261 | obese | "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Agrptm1(cre)Lowl/Agrp+ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Foxp3tm1Tch/Y,Stat6tm1Gru/Stat6tm1Gru Genetic Background: C.129-Stat6tm1Gru Foxp3tm1Tch
Allelic Composition: Agrptm2(DTR)Rpa/Agrp+ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Tg(Pomc-EGFP)1Low/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Ay/a,Agrptm2(DTR)Rpa/Agrp+ Genetic Background: involves: 129S4/SvJaeSor * KK/Upj
Allelic Composition: Agrptm1(cre)Lowl/Agrp+,Slc32a1tm1Lowl/Slc32a1tm1Lowl Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Foxp3tm1Tch/Y,Stat6tm1Gru/Stat6tm1Gru Genetic Background: C.129-Stat6tm1Gru Foxp3tm1Tch
Allelic Composition: Agrptm1(cre)Lowl/Agrp+,Slc32a1tm1Lowl/Slc32a1tm1Lowl Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0001431 | abnormal eating behavior | "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212] |
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Allelic Composition: Eomestm1Whk/Eomestm1Whk Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Ay/a,Agrptm2(DTR)Rpa/Agrp+ Genetic Background: involves: 129S4/SvJaeSor * KK/Upj
Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Tph2tm1Mscl/Tph2tm1Mscl Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr
Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Grin1tm2Stl/Grin1tm2Stl Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Slc17a6tm1.1Thna/Slc17a6tm1.1Thna Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J
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MP:0001657 | abnormal induced morbidity/mortality | "differences from the expected diseased state or death caused by an external intervention" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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MP:0001661 | extended life span | "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
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MP:0002089 | abnormal postnatal growth/weight/body size | "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Tph2tm1Mscl/Tph2tm1Mscl Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr
Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Grin1tm2Stl/Grin1tm2Stl Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Slc17a6tm1.1Thna/Slc17a6tm1.1Thna Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Agrptm1Sqn/Agrptm1Sqn,Npytm1Rpa/Npytm1Rpa Genetic Background: involves: 129S7/SvEvBrd
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MP:0002945 | abnormal inhibitory postsynaptic currents | "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Tg(Pomc-EGFP)1Low/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Agrptm1(cre)Lowl/Agrp+,Slc32a1tm1Lowl/Slc32a1tm1Lowl Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0003458 | decreased circulating ketone body level | "less than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Agrp-cre)1Gsb/0 Genetic Background: involves: 129 * FVB/N
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MP:0003961 | decreased lean body mass | "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator] |
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Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
Allelic Composition: Agrptm1Dgen/Agrptm1Dgen Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0003964 | abnormal noradrenaline level | "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Agrptm1Dgen/Agrptm1Dgen Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0003976 | decreased circulating VLDL triglyceride level | "lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Agrptm1Dgen/Agrptm1Dgen Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0003983 | decreased cholesterol level | "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Agrptm1Mws/Agrptm1Mws Genetic Background: B6.129S1-Agrptm1Mws
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MP:0005111 | hyperdipsia | "intense thirst that is relatively temporary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83217] |
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Allelic Composition: Agrptm2(DTR)Rpa/Agrptm2(DTR)Rpa Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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MP:0005289 | increased oxygen consumption | "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Agrptm1(cre)Lowl/Agrp+,Slc32a1tm1Lowl/Slc32a1tm1Lowl Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0005292 | improved glucose tolerance | "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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MP:0005449 | abnormal food intake | "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Foxp3tm1Tch/Y,Stat6tm1Gru/Stat6tm1Gru Genetic Background: C.129-Stat6tm1Gru Foxp3tm1Tch
Allelic Composition: Agrptm1(cre)Lowl/Agrp+,Slc32a1tm1Lowl/Slc32a1tm1Lowl Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0005450 | abnormal energy expenditure | "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
Allelic Composition: Agrptm1Mws/Agrptm1Mws Genetic Background: B6.129S1-Agrptm1Mws
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MP:0005477 | increased circulating thyroxine level | "greater than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Agrptm1Mws/Agrptm1Mws Genetic Background: B6.129S1-Agrptm1Mws
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MP:0005480 | increased circulating triiodothyronine level | "greater than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Agrptm1Mws/Agrptm1Mws Genetic Background: B6.129S1-Agrptm1Mws
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MP:0005534 | decreased body temperature | "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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MP:0005659 | resistance to diet-induced obesity | "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator] |
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Allelic Composition: Agrptm1(cre)Lowl/Agrp+,Slc32a1tm1Lowl/Slc32a1tm1Lowl Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0005668 | decreased circulating leptin level | "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751] |
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Allelic Composition: Agrptm1Mws/Agrptm1Mws Genetic Background: B6.129S1-Agrptm1Mws
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MP:0008948 | decreased neuron number | "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663] |
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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MP:0009288 | increased epididymal fat pad weight | |
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Agrptm1(cre)Lowl/Agrp+ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
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MP:0009298 | increased mesenteric fat pad weight | |
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Agrptm1(cre)Lowl/Agrp+ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
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MP:0009302 | increased renal fat pad weight | |
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Agrptm1(cre)Lowl/Agrp+ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
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MP:0009356 | decreased liver triglyceride level | "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agrptm1Dgen/Agrptm1Dgen Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0009642 | abnormal blood homeostasis | "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agrptm1Mws/Agrptm1Mws Genetic Background: B6.129S1-Agrptm1Mws
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MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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MP:0010024 | increased total body fat amount | "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Agrptm1(cre)Lowl/Agrp+ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
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MP:0010025 | decreased total body fat amount | "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agrptm1Mws/Agrptm1Mws Genetic Background: B6.129S1-Agrptm1Mws
Allelic Composition: Agrptm1(cre)Lowl/Agrp+,Slc32a1tm1Lowl/Slc32a1tm1Lowl Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0010070 | decreased serotonin concentration | "reduction in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Tph2tm1Mscl/Tph2tm1Mscl Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr
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MP:0010143 | enhanced fertility | "increased ability to produce live offspring" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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MP:0010180 | increased susceptibility to weight loss | "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agrptm1Dgen/Agrptm1Dgen Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0010379 | decreased respiratory quotient | "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agrptm1Mws/Agrptm1Mws Genetic Background: B6.129S1-Agrptm1Mws
Allelic Composition: Agrptm1(cre)Lowl/Agrp+,Slc32a1tm1Lowl/Slc32a1tm1Lowl Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0011016 | increased core body temperature | "increased degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agrptm1Mws/Agrptm1Mws Genetic Background: B6.129S1-Agrptm1Mws
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MP:0011049 | impaired adaptive thermogenesis | "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744] |
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Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
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MP:0011939 | increased food intake | "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith] |
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Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
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MP:0011940 | decreased food intake | "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith] |
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Allelic Composition: Ay/a,Agrptm2(DTR)Rpa/Agrp+ Genetic Background: involves: 129S4/SvJaeSor * KK/Upj
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