ENSMUSG00000005716


Mus musculus

Features
Gene ID: ENSMUSG00000005716
  
Biological name :Pvalb
  
Synonyms : P32848 / parvalbumin / Pvalb
  
Possible biological names infered from orthology : P20472
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 78191114
Gene end: 78206400
  
Corresponding Affymetrix probe sets: 10430297 (MoGene1.0st)   1417653_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005860
Ensembl peptide - ENSMUSP00000112598
NCBI entrez gene - 19293     See in Manteia.
MGI - MGI:97821
RefSeq - XM_006520643
RefSeq - NM_001330686
RefSeq - NM_013645
RefSeq Peptide - NP_038673
RefSeq Peptide - NP_001317615
swissprot - P32848
swissprot - Q545M7
Ensembl - ENSMUSG00000005716
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pvalb6ENSDARG00000009311Danio rerio
 pvalb7ENSDARG00000034705Danio rerio
 PVALBENSGALG00000012522Gallus gallus
 PVALBENSG00000100362Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ocm / P51879 / Oncomodulin / OCM2* / P0CE71* / P0CE72* / oncomodulin 2*ENSMUSG0000002961845


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR008080  Parvalbumin
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000436 abnormal head movements "anomalous motion of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Pvalbtm1Swal/Pvalbtm1Swal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Mapttm2Arbr/Mapt+,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pvalbtm1(cre)Arbr/Pvalb+,Slc12a6tm2.1Dlp/Slc12a6tm2.1Dlp
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mecp2tm1Bird/Y,Pvalbtm1.1(cre)Aibs/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Hprttm1(CAG-Glra3*)Jcme/Y,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Mecp2tm1Bird/Y,Pvalbtm1.1(cre)Aibs/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Erbb4tm1Fej/Erbb4tm1Fej,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129 * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mecp2tm1Bird/Y,Pvalbtm1.1(cre)Aibs/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Allelic Composition: Pvalbtm1(cre)Arbr/Pvalb+,Slc12a6tm2.1Dlp/Slc12a6tm2.1Dlp
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Mecp2tm1Bird/Y,Pvalbtm1.1(cre)Aibs/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0001408 stereotypic behavior "repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Ptentm1Mro/Pten+,Sdhbtm1.1Ics/Sdhb+,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129S2/SvPas * FVB

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Mecp2tm1Bird/Y,Pvalbtm1.1(cre)Aibs/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm1(CAG-Glra3*)Jcme/Y,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mecp2tm1Bird/Y,Pvalbtm1.1(cre)Aibs/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Pvalbtm1.1(cre)Aibs/Pvalb+
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Pvalbtm3.1(dreo)Hze/Pvalb+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

Allelic Composition: Pvalbtm5.1(cre/folA)Hze/Pvalb+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl

Allelic Composition: Pvalbtm2(cre/ERT2)Zjh/Pvalbtm2(cre/ERT2)Zjh
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hprttm1(CAG-Glra3*)Jcme/Y,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hprttm1(CAG-Glra3*)Jcme/Y,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Erbb4tm1Fej/Erbb4tm1Fej,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129 * C57BL/6

 MP:0004167 abnormal cingulate gyrus morphology "any malformation or absence of the ridge in the cerebral cortex located dorsal to the corpus callosum that controls autonomic functions regulating heart rate and blood pressure as well as cognitive and attentional processing" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gclmtm1Tdal/Gclmtm1Tdal
Genetic Background: B6.129-Gclmtm1Tdal

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005620 abnormal muscle contractility "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Xpctm1Ecf/Xpctm1Ecf
Genetic Background: involves: 129

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pvalbtm1Swal/Pvalbtm1Swal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb4tm1Fej/Erbb4tm1Fej,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129 * C57BL/6

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm1Bird/Y,Pvalbtm1.1(cre)Aibs/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0012306 enhanced spatial learning "enhanced ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012318 slow extinction of fear memory "impaired ability or inability to extinguish aversive memories associated with a traumatic incident" [http://www.mpipsykl.mpg.de/en/research/themes/depression/wotjak_02/]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020395 abnormal response to social novelty "any anomaly in the interaction of an individual with a familiar versus a novel individual of the same species; in mouse the typical behavior is is for increased interaction with the novel individual" [PMID:23280234]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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