ENSMUSG00000005718


Mus musculus

Features
Gene ID: ENSMUSG00000005718
  
Biological name :Tfap4
  
Synonyms : Tfap4 / transcription factor AP4
  
Possible biological names infered from orthology : Q01664
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A1
Gene start: 4544661
Gene end: 4559854
  
Corresponding Affymetrix probe sets: 10437384 (MoGene1.0st)   1418167_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005862
Ensembl peptide - ENSMUSP00000155303
Ensembl peptide - ENSMUSP00000155803
NCBI entrez gene - 83383     See in Manteia.
MGI - MGI:103239
RefSeq - XM_017317166
RefSeq - NM_031182
RefSeq - XM_006522766
RefSeq - XM_011246047
RefSeq - XM_006522762
RefSeq - XM_006522763
RefSeq - XM_006522764
RefSeq - XM_006522765
RefSeq Peptide - NP_112459
swissprot - Q9JIZ5
Ensembl - ENSMUSG00000005718
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfap4ENSDARG00000103923Danio rerio
 TFAP4ENSGALG00000027823Gallus gallus
 TFAP4ENSG00000090447Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043392 negative regulation of DNA binding IEA
 biological_processGO:0043922 negative regulation by host of viral transcription IEA
 biological_processGO:0043923 positive regulation by host of viral transcription IEA
 biological_processGO:0044772 mitotic cell cycle phase transition ISS
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:0071157 negative regulation of cell cycle arrest IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IDA
 biological_processGO:1901990 regulation of mitotic cell cycle phase transition IEA
 biological_processGO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0017053 transcriptional repressor complex IMP
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/?
Genetic Background: involves: BALB/c * C57BL/6 * NZB

Allelic Composition: Cd4tm2Litt/Cd4tm2Litt,Tfap4tm1.1Litt/Tfap4tm1.1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/?
Genetic Background: involves: BALB/c * C57BL/6 * NZB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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