ENSMUSG00000006304


Mus musculus

Features
Gene ID: ENSMUSG00000006304
  
Biological name :Arpc2
  
Synonyms : Arpc2 / Mus musculus actin related protein 2/3 complex, subunit 2 (Arpc2), transcript variant 2, mRNA. / Q9CVB6
  
Possible biological names infered from orthology : actin related protein 2/3 complex subunit 2 / O15144
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C3
Gene start: 74236084
Gene end: 74268209
  
Corresponding Affymetrix probe sets: 10347297 (MoGene1.0st)   1437148_at (Mouse Genome 430 2.0 Array)   1442295_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109451
Ensembl peptide - ENSMUSP00000140762
Ensembl peptide - ENSMUSP00000006467
Ensembl peptide - ENSMUSP00000109450
NCBI entrez gene - 76709     See in Manteia.
MGI - MGI:1923959
RefSeq - NM_029711
RefSeq - XM_006496317
RefSeq - NM_001357387
RefSeq Peptide - NP_001344316
RefSeq Peptide - NP_083987
swissprot - A0A087WRT2
swissprot - Q9CVB6
swissprot - D3YXG6
Ensembl - ENSMUSG00000006304
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arpc2ENSDARG00000075989Danio rerio
 ARPC2ENSGALG00000011452Gallus gallus
 ARPC2ENSG00000163466Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007188  Actin-related protein 2/3 complex subunit 2
 IPR034666  Arp2/3 complex subunit 2/4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010592 positive regulation of lamellipodium assembly ISO
 biological_processGO:0030041 actin filament polymerization IEA
 biological_processGO:0030833 regulation of actin filament polymerization IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IDA
 biological_processGO:0034314 Arp2/3 complex-mediated actin nucleation IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005885 Arp2/3 protein complex IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0036195 muscle cell projection membrane IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051015 actin filament binding IBA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
RHO GTPases Activate WASPs and WAVEs
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ap4e1tm1a(KOMP)Wtsi/Ap4e1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ap4e1tm1a(KOMP)Wtsi/Wtsi

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ap4e1tm1a(KOMP)Wtsi/Ap4e1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ap4e1tm1a(KOMP)Wtsi/Wtsi

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ap4e1tm1a(KOMP)Wtsi/Ap4e1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ap4e1tm1a(KOMP)Wtsi/Wtsi

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ap4e1tm1a(KOMP)Wtsi/Ap4e1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ap4e1tm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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