ENSMUSG00000006517


Mus musculus

Features
Gene ID: ENSMUSG00000006517
  
Biological name :Mvd
  
Synonyms : mevalonate (diphospho) decarboxylase / Mvd / Q99JF5
  
Possible biological names infered from orthology : mevalonate diphosphate decarboxylase / P53602
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E1
Gene start: 122433601
Gene end: 122443422
  
Corresponding Affymetrix probe sets: 10582310 (MoGene1.0st)   1417303_at (Mouse Genome 430 2.0 Array)   1448663_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148539
Ensembl peptide - ENSMUSP00000006692
NCBI entrez gene - 192156     See in Manteia.
MGI - MGI:2179327
RefSeq - NM_138656
RefSeq Peptide - NP_619597
swissprot - A0A1D5RLX3
swissprot - Q3UYC1
swissprot - Q99JF5
Ensembl - ENSMUSG00000006517
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mvdaENSDARG00000099336Danio rerio
 MVDENSGALG00000007267Gallus gallus
 MVDENSG00000167508Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005935  Diphosphomevalonate/phosphomevalonate decarboxylase
 IPR006204  GHMP kinase N-terminal domain
 IPR014721  Ribosomal protein S5 domain 2-type fold, subgroup
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR029765  Diphosphomevalonate decarboxylase
 IPR036554  GHMP kinase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006695 cholesterol biosynthetic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008299 isoprenoid biosynthetic process ISO
 biological_processGO:0016126 sterol biosynthetic process IEA
 biological_processGO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway IBA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004163 diphosphomevalonate decarboxylase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016831 carboxy-lyase activity IEA
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Cholesterol biosynthesis
Synthesis of Dolichyl-phosphate


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006517 Mvd / Q99JF5 / mevalonate (diphospho) decarboxylase / P53602* / mevalonate diphosphate decarboxylase*  / complex






 

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