ENSMUSG00000008373


Mus musculus

Features
Gene ID: ENSMUSG00000008373
  
Biological name :Prpf31
  
Synonyms : Prpf31 / Q8CCF0 / U4/U6 small nuclear ribonucleoprotein Prp31
  
Possible biological names infered from orthology : pre-mRNA processing factor 31 / Q8WWY3
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A1
Gene start: 3629985
Gene end: 3642486
  
Corresponding Affymetrix probe sets: 10549552 (MoGene1.0st)   1448633_at (Mouse Genome 430 2.0 Array)   1453005_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000008517
Ensembl peptide - ENSMUSP00000104276
Ensembl peptide - ENSMUSP00000136031
Ensembl peptide - ENSMUSP00000146017
NCBI entrez gene - 68988     See in Manteia.
MGI - MGI:1916238
RefSeq - NM_001159714
RefSeq - NM_027328
RefSeq Peptide - NP_001153186
RefSeq Peptide - NP_081604
swissprot - Q8CCF0
Ensembl - ENSMUSG00000008373
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prpf31ENSDARG00000095904Danio rerio
 PRPF31ENSG00000105618Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002687  Nop domain
 IPR012976  NOSIC
 IPR019175  Prp31 C-terminal
 IPR027105  U4/U6 small nuclear ribonucleoprotein Prp31
 IPR036070  Nop domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000244 spliceosomal tri-snRNP complex assembly ISO
 biological_processGO:0000398 mRNA splicing, via spliceosome ISO
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0071166 ribonucleoprotein complex localization ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005687 U4 snRNP ISO
 cellular_componentGO:0005690 U4atac snRNP IBA
 cellular_componentGO:0015030 Cajal body IEA
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0046540 U4/U6 x U5 tri-snRNP complex ISS
 cellular_componentGO:0071005 U2-type precatalytic spliceosome ISS
 cellular_componentGO:0071011 precatalytic spliceosome IBA
 cellular_componentGO:0071339 MLL1 complex ISO
 cellular_componentGO:0097526 spliceosomal tri-snRNP complex IBA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0030621 U4 snRNA binding ISO
 molecular_functionGO:0030622 U4atac snRNA binding ISS
 molecular_functionGO:0043021 ribonucleoprotein complex binding ISO
 molecular_functionGO:0070990 snRNP binding ISO


Pathways (from Reactome)
Pathway description
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Prpf8tm1.1Eap/Prpf8+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prpf8tm1.1Eap/Prpf8+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prokr1tm1.1(KOMP)Vlcg/Prokr1+
Genetic Background: C57BL/6N-Prokr1tm1.1(KOMP)Vlcg/Ucd

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Pkdcctm1.1Mask/Pkdcctm1.1Mask
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pkdcctm1.1Mask/Pkdcctm1.1Mask
Genetic Background: involves: C57BL/6 * CBA * FVB/N

Allelic Composition: Prpf31tm1a(EUCOMM)Wtsi/Prpf31tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Prpf31tm1a(EUCOMM)Wtsi/Nju

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Prokr1tm1.1(KOMP)Vlcg/Prokr1+
Genetic Background: C57BL/6N-Prokr1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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