ENSMUSG00000009876


Mus musculus

Features
Gene ID: ENSMUSG00000009876
  
Biological name :Cox4i2
  
Synonyms : Cox4i2 / Cytochrome c oxidase subunit 4 isoform 2, mitochondrial / Q91W29
  
Possible biological names infered from orthology : cytochrome c oxidase subunit 4I2 / Q96KJ9
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H1
Gene start: 152754173
Gene end: 152765037
  
Corresponding Affymetrix probe sets: 10477179 (MoGene1.0st)   1421373_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000010020
Ensembl peptide - ENSMUSP00000105446
NCBI entrez gene - 84682     See in Manteia.
MGI - MGI:2135755
RefSeq - XM_017319347
RefSeq - NM_053091
RefSeq Peptide - NP_444321
swissprot - Q91W29
Ensembl - ENSMUSG00000009876
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cox4i2ENSDARG00000022509Danio rerio
 COX4I2ENSG00000131055Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cox4i1 / P19783 / Cytochrome c oxidase subunit 4 isoform 1, mitochondrial / P13073* / cytochrome c oxidase subunit 4I1*ENSMUSG0000003181845


Protein motifs (from Interpro)
Interpro ID Name
 IPR004203  Cytochrome c oxidase subunit IV family
 IPR013288  Cytochrome c oxidase subunit IV
 IPR036639  Cytochrome c oxidase subunit IV superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006123 mitochondrial electron transport, cytochrome c to oxygen IBA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:1902600 proton transmembrane transport IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005751 mitochondrial respiratory chain complex IV ISA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IDA
 molecular_functionGO:0004129 cytochrome-c oxidase activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Lepob/Lepob,Steap4tm1Dgen/Steap4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Lepob/Lepob,Steap4tm1Dgen/Steap4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cox4i2tm1Hutt/Cox4i2+
Genetic Background: B6.129-Cox4i2tm1Hutt

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lepob/Lepob,Steap4tm1Dgen/Steap4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lepob/Lepob,Steap4tm1Dgen/Steap4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cox4i2tm1Hutt/Cox4i2+
Genetic Background: B6.129-Cox4i2tm1Hutt

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Lepob/Lepob,Steap4tm1Dgen/Steap4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lepob/Lepob,Steap4tm1Dgen/Steap4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lepob/Lepob,Steap4tm1Dgen/Steap4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Lepob/Lepob,Steap4tm1Dgen/Steap4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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