ENSMUSG00000010054


Mus musculus

Features
Gene ID: ENSMUSG00000010054
  
Biological name :Tusc2
  
Synonyms : Q9WVF8 / tumor suppressor candidate 2 / Tusc2
  
Possible biological names infered from orthology : O75896
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 107563255
Gene end: 107566112
  
Corresponding Affymetrix probe sets: 10588678 (MoGene1.0st)   1417593_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141635
Ensembl peptide - ENSMUSP00000010198
NCBI entrez gene - 80385     See in Manteia.
MGI - MGI:1931086
RefSeq - NM_019742
RefSeq Peptide - NP_062716
swissprot - A0A0A6YWP5
swissprot - Q542N4
swissprot - Q9WVF8
Ensembl - ENSMUSG00000010054
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tusc2aENSDARG00000099817Danio rerio
 tusc2bENSDARG00000025340Danio rerio
 TUSC2ENSGALG00000041338Gallus gallus
 TUSC2ENSG00000114383Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029393  Tumour suppressor candidate 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001779 natural killer cell differentiation IMP
 biological_processGO:0006909 phagocytosis IMP
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0032618 interleukin-15 production IMP
 biological_processGO:0032700 negative regulation of interleukin-17 production IMP
 biological_processGO:0032733 positive regulation of interleukin-10 production IMP
 biological_processGO:0048469 cell maturation IMP
 biological_processGO:0050829 defense response to Gram-negative bacterium IMP
 biological_processGO:0051881 regulation of mitochondrial membrane potential IMP
 biological_processGO:0052567 response to defense-related host reactive oxygen species production IMP
 biological_processGO:0070945 neutrophil mediated killing of gram-negative bacterium IMP
 biological_processGO:0071609 chemokine (C-C motif) ligand 5 production IMP
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001864 vasculitis "inflammation of a blood or lymph vessel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002019 abnormal tumor incidence "deviation from the expected number of abnormal growths of a specific tissue in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
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Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
Show

Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008053 abnormal NK cell differentiation "atypical production of or inability to produce the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008676 decreased interleukin-15 secretion "reduction in the production or release of a cytokine that stimulates the proliferation of T-cells and can induce proliferation and differentiation of B-cells; interleukin-15 shares biological activities with interleukin-2" [MESH:D12.644.276.374.465.515]
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Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010138 arteritis "inflammation of the walls of arteries, usually as a result of infection or auto-immune response" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
Show

Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011508 glomerular capillary thrombosis "formation or presence of a thrombus within the renal glomerular capillaries" [MGI:anna]
Show

Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0013249 adipose tissue necrosis "morphological changes resulting from pathological death of adipose tissue; usually due to irreversible damage" [MGI:csmith]
Show

Allelic Composition: Artm1Fcl/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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