ENSMUSG00000010122


Mus musculus

Features
Gene ID: ENSMUSG00000010122
  
Biological name :Slc47a1
  
Synonyms : Multidrug and toxin extrusion protein 1 / Q8K0H1 / Slc47a1
  
Possible biological names infered from orthology : Q96FL8 / solute carrier family 47 member 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B2
Gene start: 61343401
Gene end: 61378345
  
Corresponding Affymetrix probe sets: 10386683 (MoGene1.0st)   1418395_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000010267
Ensembl peptide - ENSMUSP00000115132
Ensembl peptide - ENSMUSP00000118265
NCBI entrez gene - 67473     See in Manteia.
MGI - MGI:1914723
RefSeq - XM_011249189
RefSeq - XM_006533993
RefSeq - XM_006533995
RefSeq - XM_006533997
RefSeq - XM_011249188
RefSeq - NM_026183
RefSeq Peptide - NP_080459
swissprot - F6XMB0
swissprot - D6RGQ3
swissprot - Q8K0H1
Ensembl - ENSMUSG00000010122
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A1L1P9ENSDARG00000060051Danio rerio
 BX248108.1ENSDARG00000114306Danio rerio
 slc47a1ENSDARG00000046012Danio rerio
 slc47a3ENSDARG00000074561Danio rerio
 slc47a4ENSDARG00000079340Danio rerio
 Q96FL8ENSG00000142494Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3V050 / Slc47a2 / Multidrug and toxin extrusion protein 2 / Q86VL8* / solute carrier family 47 member 2*ENSMUSG0000006985554


Protein motifs (from Interpro)
Interpro ID Name
 IPR002528  Multi antimicrobial extrusion protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006855 drug transmembrane transport IEA
 biological_processGO:0015695 organic cation transport IEA
 biological_processGO:0015893 drug transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1902600 proton transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031982 vesicle IEA
 molecular_functionGO:0005451 monovalent cation:proton antiporter activity IEA
 molecular_functionGO:0015238 drug transmembrane transporter activity IEA
 molecular_functionGO:0015297 antiporter activity IEA


Pathways (from Reactome)
Pathway description
Transport of bile salts and organic acids, metal ions and amine compounds


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Taok2tm1.2Dkap/Taok2tm1.2Dkap
Genetic Background: B6(Cg)-Taok2tm1.2Dkap

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Taok2tm1.2Dkap/Taok2tm1.2Dkap
Genetic Background: B6(Cg)-Taok2tm1.2Dkap

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw,Mark3tm1Hpw/Mark3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw,Mark3tm1Hpw/Mark3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Taok2tm1.2Dkap/Taok2tm1.2Dkap
Genetic Background: B6(Cg)-Taok2tm1.2Dkap

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw,Mark3tm1Hpw/Mark3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Slc47a1Gt(IST12634F2)Tigm/Slc47a1Gt(IST12634F2)Tigm
Genetic Background: B6.B6N-Slc47a1Gt(IST12634F2)Tigm

 MP:0009641 kidney degeneration "a retrogressive impairment of function or destruction of either or both of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc47a1Gt(IST12634F2)Tigm/Slc47a1Gt(IST12634F2)Tigm
Genetic Background: B6.B6N-Slc47a1Gt(IST12634F2)Tigm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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