ENSMUSG00000010505


Mus musculus

Features
Gene ID: ENSMUSG00000010505
  
Biological name :Myt1
  
Synonyms : Myelin transcription factor 1 / Myt1 / Q8CFC2
  
Possible biological names infered from orthology : Q01538
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H4
Gene start: 181763332
Gene end: 181827797
  
Corresponding Affymetrix probe sets: 10479698 (MoGene1.0st)   1422773_at (Mouse Genome 430 2.0 Array)   1439365_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122011
Ensembl peptide - ENSMUSP00000121394
Ensembl peptide - ENSMUSP00000139356
Ensembl peptide - ENSMUSP00000079900
Ensembl peptide - ENSMUSP00000104387
Ensembl peptide - ENSMUSP00000104388
Ensembl peptide - ENSMUSP00000115697
NCBI entrez gene - 17932     See in Manteia.
MGI - MGI:1100535
RefSeq - XM_017316169
RefSeq - NM_001171616
RefSeq - NM_001171680
RefSeq - NM_008665
RefSeq - XM_006500577
RefSeq - XM_006500578
RefSeq - XM_006500579
RefSeq - XM_006500580
RefSeq - XM_006500581
RefSeq - XM_011239932
RefSeq - XM_017316167
RefSeq - NM_001171615
RefSeq Peptide - NP_032691
RefSeq Peptide - NP_001165086
RefSeq Peptide - NP_001165087
RefSeq Peptide - NP_001165151
swissprot - F6SWU2
swissprot - B0R0C1
swissprot - V9GXW7
swissprot - F7CGS5
swissprot - B0R0C6
swissprot - Q8CFC2
Ensembl - ENSMUSG00000010505
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myt1aENSDARG00000074030Danio rerio
 myt1bENSDARG00000102879Danio rerio
 MYT1ENSGALG00000005932Gallus gallus
 MYT1ENSG00000196132Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myt1l / P97500 / Myelin transcription factor 1-like protein / Q9UL68* / myelin transcription factor 1 like*ENSMUSG0000006191149
St18 / Q80TY4 / suppression of tumorigenicity 18 / O60284* / ST18, C2H2C-type zinc finger*ENSMUSG0000003374040


Protein motifs (from Interpro)
Interpro ID Name
 IPR002515  Zinc finger, C2HC-type
 IPR013681  Myelin transcription factor 1
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR036060  Zinc finger, C2HC-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001678 cellular glucose homeostasis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0032350 regulation of hormone metabolic process IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0060539 diaphragm development IMP
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Enahtm1Fbg/Enahtm1Fbg,Evltm1Fbg/Evltm1Fbg,Vasptm1Ref/Vasptm1Ref
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0002694 abnormal pancreas secretion "altered ability of the pancreas to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vsx2or-J/Vsx2or-J
Genetic Background: 129S1/Sv

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Vsx2or-J/Vsx2or-J
Genetic Background: 129S1/Sv

 MP:0003563 abnormal alpha cell physiology "anomaly in the function of the glucagon-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vsx2or-J/Vsx2or-J
Genetic Background: 129S1/Sv

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vsx2or-J/Vsx2or-J
Genetic Background: 129S1/Sv

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vsx2or-J/Vsx2or-J
Genetic Background: 129S1/Sv

 MP:0008953 abnormal pancreatic somatostatin secretion "anomaly in the production or release from pancreatic delta cells of a 14 amino acid peptide that inhibits growth hormone release and is found in the central and peripheral nervous systems, the gut, and other organs" [MESH:D06.472.699.327.700.875]
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Allelic Composition: Vsx2or-J/Vsx2or-J
Genetic Background: 129S1/Sv

 MP:0009195 abnormal PP cell physiology "any functional anomaly of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas" [CL:0000696, MESH:A03.734.414.587]
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Allelic Composition: Enahtm1Fbg/Enahtm1Fbg,Evltm1Fbg/Evltm1Fbg,Vasptm1Ref/Vasptm1Ref
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Myt1tm1Ggu/Myt1tm1.1Ggu,Tg(Pdx1-cre)89.1Dam/?
Genetic Background: involves: 129 * C57BL/6 * CBA * CD-1 * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Lrp1tm2Her/Lrp1tm2Her,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Enahtm1Fbg/Enahtm1Fbg,Evltm1Fbg/Evltm1Fbg,Vasptm1Ref/Vasptm1Ref
Genetic Background: involves: 129 * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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