ENSMUSG00000012705


Mus musculus

Features
Gene ID: ENSMUSG00000012705
  
Biological name :Retn
  
Synonyms : Q99P87 / resistin / Retn
  
Possible biological names infered from orthology : Q9HD89
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.1
Gene start: 3655770
Gene end: 3660110
  
Corresponding Affymetrix probe sets: 10569870 (MoGene1.0st)   1449182_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000012849
Ensembl peptide - ENSMUSP00000133024
NCBI entrez gene - 57264     See in Manteia.
MGI - MGI:1888506
RefSeq - NM_022984
RefSeq - NM_001204959
RefSeq Peptide - NP_001191888
RefSeq Peptide - NP_075360
swissprot - Q5BMX4
swissprot - Q99P87
Ensembl - ENSMUSG00000012705
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RETNENSG00000104918Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Retnlb / resistin like beta / Q9BQ08*ENSMUSG0000002265033
Retnlg / Q8K426 / Resistin-like gamma / Q9BQ08* / RETNLB* / resistin like beta*ENSMUSG0000002265132
Retnla / resistin like alpha / Q9BQ08* / RETNLB* / resistin like beta*ENSMUSG0000006110029


Protein motifs (from Interpro)
Interpro ID Name
 IPR009714  Resistin
 IPR036262  Resistin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0005179 hormone activity IBA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar

 MP:0003443 increased circulating glycerol level "higher than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0020386 adipose tissue inflammation "local accumulation of fluid, plasma proteins, and leukocytes in adipose tissue" [MGI:anna, PMID:24662293, PMID:24695736, PMID:26629401]
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Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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