| MP:0000689 | abnormal spleen morphology | "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0000693 | spleen hyperplasia | "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0001845 | abnormal inflammatory response | "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0001858 | intestinal inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0001860 | liver inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0001861 | lung inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
|
| MP:0002459 | abnormal B cell physiology | "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0002499 | chronic inflammation | "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0003865 | lymph node inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the lymph nodes" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0005014 | increased B cell number | "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0005015 | increased T cell number | "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0005078 | abnormal cytotoxic T cell physiology | "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0005463 | abnormal CD4+ T cell physiology | "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0006173 | abnormal Langerhans cell morphology/development | "anomaly in the formation or structure of phagocytic dendritic cells principally found in the epidemis and mucosal epithelium" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95147] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0006412 | abnormal T cell apoptosis | "change in the timing or the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008217 | abnormal B cell activation | "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008246 | abnormal leukocyte morphology | "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008478 | increased spleen white pulp amount | "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008496 | decreased IgG2a level | "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008497 | decreased IgG2b level | "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008553 | increased circulating tumor necrosis factor level | "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008560 | increased tumor necrosis factor secretion | "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008566 | increased interferon-gamma secretion | "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008593 | increased circulating interleukin-10 level | "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008596 | increased circulating interleukin-6 level | "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008617 | increased circulating interleukin-12 level | "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008641 | increased circulating interleukin-1 beta level | "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008657 | increased interleukin-1 beta secretion | "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008663 | increased interleukin-12 secretion | "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008681 | increased interleukin-17 secretion | "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008687 | increased interleukin-2 secretion | "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008699 | increased interleukin-4 secretion | "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008705 | increased interleukin-6 secretion | "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008735 | increased susceptibility to endotoxin shock | "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0011075 | abnormal macrophage activation involved in immune response | "anomaly in the process in which a change in morphology and behavior of a macrophage results from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response" [GO:0002281] |
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Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1
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