ENSMUSG00000062210


Mus musculus

Features
Gene ID: ENSMUSG00000062210
  
Biological name :Tnfaip8
  
Synonyms : Q921Z5 / Tnfaip8 / Tumor necrosis factor alpha-induced protein 8
  
Possible biological names infered from orthology : O95379 / TNF alpha induced protein 8
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: D1
Gene start: 49979427
Gene end: 50107173
  
Corresponding Affymetrix probe sets: 10455647 (MoGene1.0st)   10455653 (MoGene1.0st)   1416950_at (Mouse Genome 430 2.0 Array)   1442753_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120712
Ensembl peptide - ENSMUSP00000136682
Ensembl peptide - ENSMUSP00000136665
Ensembl peptide - ENSMUSP00000136152
Ensembl peptide - ENSMUSP00000136030
Ensembl peptide - ENSMUSP00000121372
Ensembl peptide - ENSMUSP00000115396
Ensembl peptide - ENSMUSP00000119041
Ensembl peptide - ENSMUSP00000119533
NCBI entrez gene - 106869     See in Manteia.
MGI - MGI:2147191
RefSeq - XM_011246796
RefSeq - NM_001177759
RefSeq - NM_001177760
RefSeq - NM_134131
RefSeq - XM_006525479
RefSeq - XM_011246795
RefSeq Peptide - NP_001171231
RefSeq Peptide - NP_598892
RefSeq Peptide - NP_001171230
swissprot - D3Z325
swissprot - D3Z205
swissprot - D3Z0Q1
swissprot - D3YWJ5
swissprot - J3QM73
swissprot - J3QNB8
swissprot - J3QNA5
swissprot - D3Z312
swissprot - Q921Z5
Ensembl - ENSMUSG00000062210
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5ZI78ENSGALG00000027761Gallus gallus
 O95379ENSG00000145779Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3TBL6 / Tnfaip8l3 / Tumor necrosis factor alpha-induced protein 8-like protein 3 / Q5GJ75* / TNF alpha induced protein 8 like 3*ENSMUSG0000007434551
Q8K288 / Tnfaip8l1 / Tumor necrosis factor alpha-induced protein 8-like protein 1 / Q8WVP5* / TNF alpha induced protein 8 like 1*ENSMUSG0000004446950
Q9D8Y7 / Tnfaip8l2 / Tumor necrosis factor alpha-induced protein 8-like protein 2 / Q6P589* / TNF alpha induced protein 8 like 2*ENSMUSG0000001370748


Protein motifs (from Interpro)
Interpro ID Name
 IPR008477  Tumor necrosis factor alpha-induced protein 8-like
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0032611 interleukin-1 beta production IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA


Pathways (from Reactome)
Pathway description
PI Metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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