ENSMUSG00000014232


Mus musculus

Features
Gene ID: ENSMUSG00000014232
  
Biological name :Cluap1
  
Synonyms : Cluap1 / Clusterin-associated protein 1 / Q8R3P7
  
Possible biological names infered from orthology : Q96AJ1
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A1
Gene start: 3908801
Gene end: 3941147
  
Corresponding Affymetrix probe sets: 10433228 (MoGene1.0st)   1424388_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121029
Ensembl peptide - ENSMUSP00000043397
Ensembl peptide - ENSMUSP00000116855
Ensembl peptide - ENSMUSP00000119490
NCBI entrez gene - 76779     See in Manteia.
MGI - MGI:1924029
RefSeq - XM_017317157
RefSeq - XM_006522701
RefSeq - XM_006522702
RefSeq - XM_006522703
RefSeq - XM_006522704
RefSeq - XM_006522705
RefSeq - NM_029738
RefSeq Peptide - NP_084014
swissprot - F6TQ80
swissprot - E9Q8M4
swissprot - D3Z1F2
swissprot - Q8R3P7
Ensembl - ENSMUSG00000014232
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cluap1ENSDARG00000079110Danio rerio
 CLUAP1ENSGALG00000030877Gallus gallus
 CLUAP1ENSG00000103351Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm20695 / CLUAP1* / Q96AJ1* / clusterin associated protein 1*ENSMUSG0000009357541


Protein motifs (from Interpro)
Interpro ID Name
 IPR019366  Clusterin-associated protein-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0021508 floor plate formation IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0035082 axoneme assembly IMP
 biological_processGO:0042073 intraciliary transport IC
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0060972 left/right pattern formation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0030992 intraciliary transport particle B IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0097542 ciliary tip IDA
 cellular_componentGO:0097546 ciliary base IDA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Intraflagellar transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
Show

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0004132 absent embryonic cilia "absence of cilia on the cells of the embryonic node " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

Allelic Composition: Cluap1tm1.2Hmd/Cluap1tm1.2Hmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0004188 delayed embryo turning "completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
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Allelic Composition: Cluap1tm1.2Hmd/Cluap1tm1.2Hmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cluap1tm1.2Hmd/Cluap1tm1.2Hmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0010117 abnormal lateral plate mesoderm "anomaly of the portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cluap1tm1.2Hmd/Cluap1tm1.2Hmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0011068 abnormal ependyma motile cilium physiology "any functional anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain and the central canal of the spinal cord, which beat in concert and to move cerebrospinal fluid around the central nervous system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cluap1tm1.2Hmd/Cluap1tm1.2Hmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cluap1tm1.2Hmd/Cluap1tm1.2Hmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cluap1tm1.2Hmd/Cluap1tm1.2Hmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0011998 decreased embryonic cilium length "reduced length of the cilia of the mouse embryo found on the cells of the embryonic node" [MGI:csmith]
Show

Allelic Composition: Cluap1tm1.2Hmd/Cluap1tm1.2Hmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0012270 cardiac edema "abnormal accumulation of fluid in the interstitial tissues and cavities of the body due to impaired cardiac function or congestive heart failure; usually characterized by increased venous and capillary pressures and often associated with renal sodium retention" [MGI:anna]
Show

Allelic Composition: Cluap1tm1.2Hmd/Cluap1tm1.2Hmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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