MP:0000208 | decreased hematocrit | "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
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MP:0000248 | macrocytosis | "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
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MP:0000263 | absent organized vascular network | "formation of vasculature, but failure to differentiate into stereotypic organized pattern" [J:53370] |
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2
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MP:0000689 | abnormal spleen morphology | "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463] |
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
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MP:0001723 | disorganized vascular plexus | |
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Piezo1tm1a(KOMP)Wtsi/Piezo1tm1a(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0002590 | increased mean corpuscular volume | "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
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MP:0002875 | decreased erythrocyte count | "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
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MP:0003229 | abnormal vitelline vasculature | "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257] |
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Allelic Composition: Piezo1tm1a(KOMP)Wtsi/Piezo1tm1a(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
Allelic Composition: Piezo1tm1c(KOMP)Wtsi/Piezo1tm1c(KOMP)Wtsi,Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0003657 | abnormal erythrocyte lysis | "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
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MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Piezo1tm1a(KOMP)Wtsi/Piezo1tm1a(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
Allelic Composition: Piezo1tm1c(KOMP)Wtsi/Piezo1tm1c(KOMP)Wtsi,Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0004003 | abnormal vascular endothelial cell physiology | "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Piezo1tm1a(KOMP)Wtsi/Piezo1tm1a(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0004076 | abnormal vitelline vascular remodelling | "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2
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MP:0004231 | abnormal calcium ion homeostasis | "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
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MP:0005312 | pericardial effusion | "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2
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MP:0005561 | increased mean corpuscular hemoglobin | "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
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MP:0005584 | abnormal enzyme/coenzyme activity | "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Piezo1tm1a(KOMP)Wtsi/Piezo1tm1a(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0005642 | decreased mean corpuscular hemoglobin concentration | "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936] |
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
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MP:0006055 | abnormal vascular endothelial cell morphology | "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Piezo1tm1a(KOMP)Wtsi/Piezo1tm1a(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
Allelic Composition: Piezo1tm1a(KOMP)Wtsi/Piezo1+ Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0008826 | abnormal splenic cell ratio | "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"] |
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
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MP:0008998 | decreased blood osmolality | "decrease in the concentration of ions in the blood compared to the normal state" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"] |
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
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MP:0009577 | abnormal developmental vascular remodeling | "any anomaly in the process by which existing vessels are reorganized during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2
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MP:0010067 | increased red blood cell distribution width | "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"] |
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
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MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Piezo1tm1a(KOMP)Wtsi/Piezo1tm1a(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0011100 | complete preweaning lethality | "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Nphp1tm1.1(KOMP)Vlcg/Nphp1tm1.1(KOMP)Vlcg Genetic Background: C57BL/6N-Nphp1tm1.1(KOMP)Vlcg/Ucd
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MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Piezo1tm1a(KOMP)Wtsi/Piezo1tm1a(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0012253 | abnormal intersomitic vessel morphology | "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna] |
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2
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MP:0012384 | abnormal erythrocyte ion transport | "aberrant measurable or observable characteristic related to the movement in red blood cells of atoms carrying an electric charge" [MPD:Molly] |
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
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MP:0012664 | decreased circulating haptoglobin level | |
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
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