ENSMUSG00000014959


Mus musculus

Features
Gene ID: ENSMUSG00000014959
  
Biological name :Gorasp2
  
Synonyms : golgi reassembly stacking protein 2 / Gorasp2 / Q99JX3
  
Possible biological names infered from orthology : Q9H8Y8
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C2
Gene start: 70661576
Gene end: 70712636
  
Corresponding Affymetrix probe sets: 10472724 (MoGene1.0st)   1424710_a_at (Mouse Genome 430 2.0 Array)   1460460_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028509
Ensembl peptide - ENSMUSP00000121549
Ensembl peptide - ENSMUSP00000107824
Ensembl peptide - ENSMUSP00000107820
NCBI entrez gene - 70231     See in Manteia.
MGI - MGI:2135962
RefSeq - NM_027352
RefSeq Peptide - NP_081628
swissprot - A2ATI8
swissprot - A2ATI6
swissprot - A2ATI9
swissprot - Q99JX3
Ensembl - ENSMUSG00000014959
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gorasp2ENSDARG00000015126Danio rerio
 GORASP2ENSGALG00000009583Gallus gallus
 Q9H8Y8ENSG00000115806Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91X51 / Gorasp1 / golgi reassembly stacking protein 1 / Q9BQQ3*ENSMUSG0000003251340


Protein motifs (from Interpro)
Interpro ID Name
 IPR007583  GRASP55/65
 IPR024958  GRASP55/65 PDZ-like domain
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006996 organelle organization IEA
 biological_processGO:0007030 Golgi organization IBA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Golgi Cisternae Pericentriolar Stack Reorganization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
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Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
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Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0011743 abnormal Golgi apparatus morphology "any structural anomaly of the compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack; Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations" [GO:0005794, MGI:mberry]
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Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026577 Blzf1 / Q8R2X8 / Golgin-45 / Q9H2G9* / basic leucine zipper nuclear factor 1*  / complex
 ENSMUSG00000047187 Rab2a / P53994 / Ras-related protein Rab-2A / P61019* / RAB2A, member RAS oncogene family*  / complex






 

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