ENSMUSG00000015112


Mus musculus

Features
Gene ID: ENSMUSG00000015112
  
Biological name :Slc25a13
  
Synonyms : Q9QXX4 / Slc25a13 / solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
  
Possible biological names infered from orthology : Q9UJS0 / solute carrier family 25 member 13
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A1
Gene start: 6041218
Gene end: 6217173
  
Corresponding Affymetrix probe sets: 10543031 (MoGene1.0st)   1449481_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015256
Ensembl peptide - ENSMUSP00000139571
NCBI entrez gene - 50799     See in Manteia.
MGI - MGI:1354721
RefSeq - XM_006505137
RefSeq - NM_001177572
RefSeq - NM_015829
RefSeq - XM_006505136
RefSeq Peptide - NP_001171043
RefSeq Peptide - NP_056644
swissprot - Q9QXX4
Ensembl - ENSMUSG00000015112
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc25a13ENSDARG00000099353Danio rerio
 SLC25A13ENSGALG00000009728Gallus gallus
 Q9UJS0ENSG00000004864Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BH59 / Slc25a12 / solute carrier family 25 (mitochondrial carrier, Aralar), member 12 / O75746* / solute carrier family 25 member 12*ENSMUSG0000002701077
Q9DB41 / Slc25a18 / solute carrier family 25 (mitochondrial carrier), member 18 / Q9H1K4* / solute carrier family 25 member 18*ENSMUSG0000000490220
Q9D6M3 / Slc25a22 / solute carrier family 25 (mitochondrial carrier, glutamate), member 22 / Q9H936* / solute carrier family 25 member 22*ENSMUSG0000001908220
Q8BGF9 / Slc25a44 / solute carrier family 25, member 44 / Q96H78*ENSMUSG0000005014413


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR002067  Mitochondrial carrier protein
 IPR011992  EF-hand domain pair
 IPR018108  Mitochondrial substrate/solute carrier
 IPR023395  Mitochondrial carrier domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006754 ATP biosynthetic process IEA
 biological_processGO:0015810 aspartate transmembrane transport IEA
 biological_processGO:0015813 L-glutamate transmembrane transport IEA
 biological_processGO:0043490 malate-aspartate shuttle IEA
 biological_processGO:0045333 cellular respiration IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070778 L-aspartate transmembrane transport IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0005313 L-glutamate transmembrane transporter activity IEA
 molecular_functionGO:0005509 calcium ion binding ISO
 molecular_functionGO:0015183 L-aspartate transmembrane transporter activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Gluconeogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0000036 absent semicircular canals "missing organ of balance; consists of three bony tubes within which the semicircular ducts are located" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0000037 abnormal lateral semicircular canal "anomaly of the lateral long bony tube of the labyrinth that is involved in the sense of balance " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0000041 absent endolymphatic duct "missing small membranous canal of the inner ear; connecting membranous labyrinth with the endolymphatic sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

Allelic Composition: Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.129-Slc25a13tm1Lct

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: B6.Cg-Gpd2tm1Tka

 MP:0002428 abnormal semicircular canal "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

Allelic Composition: Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.129-Slc25a13tm1Lct

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

Allelic Composition: Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.129-Slc25a13tm1Lct

 MP:0002730 head shaking "compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0002858 abnormal posterior semicircular canal "anomaly of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0003069 abnormal superior semicircular canal "anomaly of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0003148 reduced cochlear coiling "a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [J:56294, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0003169 abnormal scala media morphology "any malformation or absence of the division of the spiral canal of the cochlea that contains the organ of Corti (the neuroepithelial receptor organ for hearing)" [J:23837, J:46972, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: either: 129/Sv-Slc25a13tm1Lct or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Slc25a13tm1Lct/Slc25a13+
Genetic Background: either: 129/Sv-Slc25a13tm1Lct or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0003443 increased circulating glycerol level "higher than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0004369 absent utricle "absence of the larger of the two sacs in the vestibule" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0005309 increased circulating ammonia level "significantly elevated levels of ammonia or its compounds in blood; often associated with liver failure and hepatic encephalopathy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83263]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

Allelic Composition: Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: either: 129/Sv-Slc25a13tm1Lct or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Slc25a13tm1Lct/Slc25a13+
Genetic Background: either: 129/Sv-Slc25a13tm1Lct or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0006013 absent endolymphatic sac "absence of the dilated blind extremity of the endolymphatic duct, which lies external to the dura on the posterior aspect of the petrous part of the temporal bone" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:1776:]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

Allelic Composition: Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.129-Slc25a13tm1Lct

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: either: 129/Sv-Slc25a13tm1Lct or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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