ENSMUSG00000027010


Mus musculus

Features
Gene ID: ENSMUSG00000027010
  
Biological name :Slc25a12
  
Synonyms : Q8BH59 / Slc25a12 / solute carrier family 25 (mitochondrial carrier, Aralar), member 12
  
Possible biological names infered from orthology : O75746 / solute carrier family 25 member 12
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C2
Gene start: 71271063
Gene end: 71367749
  
Corresponding Affymetrix probe sets: 10483604 (MoGene1.0st)   1428440_at (Mouse Genome 430 2.0 Array)   1436440_at (Mouse Genome 430 2.0 Array)   1444489_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122103
Ensembl peptide - ENSMUSP00000139371
NCBI entrez gene - 78830     See in Manteia.
MGI - MGI:1926080
RefSeq - XM_011239853
RefSeq - NM_172436
RefSeq - XM_006500420
RefSeq Peptide - NP_766024
swissprot - V9GXX9
swissprot - Q8BH59
Ensembl - ENSMUSG00000027010
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLC25A12ENSGALG00000009545Gallus gallus
 O75746ENSG00000115840Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9QXX4 / Slc25a13 / solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 / Q9UJS0* / solute carrier family 25 member 13*ENSMUSG0000001511277
Q9DB41 / Slc25a18 / solute carrier family 25 (mitochondrial carrier), member 18 / Q9H1K4* / solute carrier family 25 member 18*ENSMUSG0000000490220
Q9D6M3 / Slc25a22 / solute carrier family 25 (mitochondrial carrier, glutamate), member 22 / Q9H936* / solute carrier family 25 member 22*ENSMUSG0000001908220
Q8BGF9 / Slc25a44 / solute carrier family 25, member 44 / Q96H78*ENSMUSG0000005014413


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR002067  Mitochondrial carrier protein
 IPR011992  EF-hand domain pair
 IPR018108  Mitochondrial substrate/solute carrier
 IPR018247  EF-Hand 1, calcium-binding site
 IPR023395  Mitochondrial carrier domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015810 aspartate transmembrane transport IEA
 biological_processGO:0015813 L-glutamate transmembrane transport IEA
 biological_processGO:0043490 malate-aspartate shuttle IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070778 L-aspartate transmembrane transport IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0005313 L-glutamate transmembrane transporter activity IEA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0015183 L-aspartate transmembrane transporter activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Gluconeogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hey1tm2Gess/Hey1tm2Gess
Genetic Background: B6.129-Hey1tm2Gess

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hey1tm2Gess/Hey1tm2Gess
Genetic Background: B6.129-Hey1tm2Gess

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hey1tm2Gess/Hey1tm2Gess
Genetic Background: B6.129-Hey1tm2Gess

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Hey1tm2Gess/Hey1tm2Gess
Genetic Background: B6.129-Hey1tm2Gess

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hey1tm2Gess/Hey1tm2Gess
Genetic Background: B6.129-Hey1tm2Gess

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Hey1tm2Gess/Hey1tm2Gess
Genetic Background: B6.129-Hey1tm2Gess

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hey1tm2Gess/Hey1tm2Gess
Genetic Background: B6.129-Hey1tm2Gess

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hey1tm2Gess/Hey1tm2Gess
Genetic Background: B6.129-Hey1tm2Gess

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Hey1tm2Gess/Hey1tm2Gess
Genetic Background: B6.129-Hey1tm2Gess

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hey1tm2Gess/Hey1tm2Gess
Genetic Background: B6.129-Hey1tm2Gess

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
Show

Allelic Composition: Hey1tm2Gess/Hey1tm2Gess
Genetic Background: B6.129-Hey1tm2Gess

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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