ENSMUSG00000015316


Mus musculus

Features
Gene ID: ENSMUSG00000015316
  
Biological name :Slamf1
  
Synonyms : Q9QUM4 / signaling lymphocytic activation molecule family member 1 / Slamf1
  
Possible biological names infered from orthology : Q13291
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H3
Gene start: 171767127
Gene end: 171801184
  
Corresponding Affymetrix probe sets: 10351667 (MoGene1.0st)   1425569_a_at (Mouse Genome 430 2.0 Array)   1425570_at (Mouse Genome 430 2.0 Array)   1425571_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015460
NCBI entrez gene - 27218     See in Manteia.
MGI - MGI:1351314
RefSeq - XM_006496873
RefSeq - NM_013730
RefSeq - XM_006496872
RefSeq Peptide - NP_038758
swissprot - Q9QUM4
swissprot - Q544K1
Ensembl - ENSMUSG00000015316
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000046393Gallus gallus
 Q13291ENSG00000117090Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007110  Immunoglobulin-like domain
 IPR010407  Signaling lymphocytic activation molecule, N-terminal
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001779 natural killer cell differentiation IMP
 biological_processGO:0001787 natural killer cell proliferation IMP
 biological_processGO:0002232 leukocyte chemotaxis involved in inflammatory response IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002277 myeloid dendritic cell activation involved in immune response ISO
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002725 negative regulation of T cell cytokine production IDA
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010759 positive regulation of macrophage chemotaxis IMP
 biological_processGO:0031338 regulation of vesicle fusion IMP
 biological_processGO:0032695 negative regulation of interleukin-12 production ISO
 biological_processGO:0032715 negative regulation of interleukin-6 production ISO
 biological_processGO:0032720 negative regulation of tumor necrosis factor production ISO
 biological_processGO:0035744 T-helper 1 cell cytokine production IDA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046330 positive regulation of JNK cascade ISO
 biological_processGO:0046649 lymphocyte activation IEA
 biological_processGO:0050790 regulation of catalytic activity IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:1902714 negative regulation of interferon-gamma secretion IDA
 biological_processGO:1902715 positive regulation of interferon-gamma secretion IDA
 biological_processGO:2000349 negative regulation of CD40 signaling pathway ISO
 biological_processGO:2000510 positive regulation of dendritic cell chemotaxis IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrattm1.1Bok/Lrattm1.1Bok
Genetic Background: involves: 129S2/SvPas

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrattm1.1Bok/Lrattm1.1Bok
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Slamf1tm1Oono/Slamf1tm1Oono
Genetic Background: B6.129-Slamf1tm1Oono Ifnar1tm1Agt

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Slamf1tm1Cpt/Slamf1tm1Cpt
Genetic Background: C.129S4-Slamf1tm1Cpt

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Slamf1tm1Cpt/Slamf1tm1Cpt
Genetic Background: C.129S4-Slamf1tm1Cpt

Allelic Composition: Slamf1tm1Cpt/Slamf1tm1Cpt,Tg(DO11.10)10Dlo/Tg(DO11.10)10Dlo
Genetic Background: involves: BALB/c * C3H * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcn4tm1Jsr/Hcn4tm1(cre/ERT2)Anlu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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