ENSMUSG00000015337


Mus musculus

Features
Gene ID: ENSMUSG00000015337
  
Biological name :Endog
  
Synonyms : Endog / Endonuclease G, mitochondrial / O08600
  
Possible biological names infered from orthology : endonuclease G / Q14249
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 30171493
Gene end: 30174069
  
Corresponding Affymetrix probe sets: 10470950 (MoGene1.0st)   1421097_at (Mouse Genome 430 2.0 Array)   1438317_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015481
NCBI entrez gene - 13804     See in Manteia.
MGI - MGI:1261433
RefSeq - NM_007931
RefSeq Peptide - NP_031957
swissprot - O08600
swissprot - Q3UN47
Ensembl - ENSMUSG00000015337
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 endogENSDARG00000058865Danio rerio
 ENDOGENSGALG00000026221Gallus gallus
 ENDOGENSG00000167136Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Exog / Q8C163 / Nuclease EXOG, mitochondrial / Q9Y2C4* / exo/endonuclease G*ENSMUSG0000004278733


Protein motifs (from Interpro)
Interpro ID Name
 IPR001604  DNA/RNA non-specific endonuclease
 IPR018524  DNA/RNA non-specific endonuclease, active site
 IPR020821  Extracellular Endonuclease, subunit A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006308 DNA catabolic process TAS
 biological_processGO:0006309 apoptotic DNA fragmentation IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0034612 response to tumor necrosis factor IMP
 biological_processGO:0036475 neuron death in response to oxidative stress IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0046677 response to antibiotic IMP
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death IEA
 biological_processGO:1902512 positive regulation of apoptotic DNA fragmentation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004536 deoxyribonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcg8tm1Elk/Abcg8+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Endogtm1Vdaw/Endogtm1Vdaw
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nbl1tm2Rmh/Nbl1tm2Rmh
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nbl1tm2Rmh/Nbl1tm2Rmh
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nbl1tm2Rmh/Nbl1tm2Rmh
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Nbl1tm2Rmh/Nbl1tm2Rmh
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac) or (involves: 129P2/OlaHsd * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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