ENSMUSG00000015790


Mus musculus

Features
Gene ID: ENSMUSG00000015790
  
Biological name :Surf1
  
Synonyms : P09925 / Surf1 / Surfeit locus protein 1
  
Possible biological names infered from orthology : Q15526 / SURF1, cytochrome c oxidase assembly factor
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 26913381
Gene end: 26916530
  
Corresponding Affymetrix probe sets: 10481135 (MoGene1.0st)   1450561_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128488
Ensembl peptide - ENSMUSP00000139112
Ensembl peptide - ENSMUSP00000141918
Ensembl peptide - ENSMUSP00000141317
Ensembl peptide - ENSMUSP00000141305
Ensembl peptide - ENSMUSP00000141238
Ensembl peptide - ENSMUSP00000015934
NCBI entrez gene - 20930     See in Manteia.
MGI - MGI:98443
RefSeq - XM_006497823
RefSeq - XM_006497821
RefSeq - XM_006497826
RefSeq - XM_006497825
RefSeq - XM_006497824
RefSeq - NM_001271724
RefSeq - NM_013677
RefSeq - XM_011239048
RefSeq Peptide - NP_038705
RefSeq Peptide - NP_001258653
swissprot - V9GXE6
swissprot - P09925
swissprot - A0A0R4J232
swissprot - A0A0A6YVR9
swissprot - A0A0A6YVX3
swissprot - A0A0A6YVY3
swissprot - A0A0A6YXB3
Ensembl - ENSMUSG00000015790
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 surf1ENSDARG00000003592Danio rerio
 SURF1ENSGALG00000033754Gallus gallus
 SURF1ENSG00000148290Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002994  Surfeit locus 1/Shy1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006119 oxidative phosphorylation IEA
 biological_processGO:0006754 ATP biosynthetic process IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0033617 mitochondrial respiratory chain complex IV assembly IEA
 biological_processGO:1902600 proton transmembrane transport IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004129 cytochrome-c oxidase activity IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

Allelic Composition: Surf1tm2.1Zev/Surf1tm2.1Zev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ybx1tm1Tuch/Ybx1tm1Tuch
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0004198 abnormal fetal size "anomalous proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Surf1tm2.1Zev/Surf1tm2.1Zev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Surf1tm2.1Zev/Surf1tm2.1Zev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Surf1tm2.1Zev/Surf1tm2.1Zev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0006038 increased mitochondrial proliferation "greater than normal reproduction of mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Surf1tm2.1Zev/Surf1tm2.1Zev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
Show

Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Surf1tm2.1Zev/Surf1tm2.1Zev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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