ENSMUSG00000015806


Mus musculus

Features
Gene ID: ENSMUSG00000015806
  
Biological name :Qdpr
  
Synonyms : Q8BVI4 / Qdpr / quinoid dihydropteridine reductase
  
Possible biological names infered from orthology : P09417
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B3
Gene start: 45434021
Gene end: 45450236
  
Corresponding Affymetrix probe sets: 10529895 (MoGene1.0st)   1423664_at (Mouse Genome 430 2.0 Array)   1437993_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113203
Ensembl peptide - ENSMUSP00000143741
Ensembl peptide - ENSMUSP00000143584
Ensembl peptide - ENSMUSP00000122081
Ensembl peptide - ENSMUSP00000115453
Ensembl peptide - ENSMUSP00000113958
Ensembl peptide - ENSMUSP00000015950
Ensembl peptide - ENSMUSP00000112469
NCBI entrez gene - 110391     See in Manteia.
MGI - MGI:97836
RefSeq - NM_024236
RefSeq Peptide - NP_077198
swissprot - A0A0G2JGY0
swissprot - A0A0G2JGJ1
swissprot - D3Z1A1
swissprot - Q8BVI4
swissprot - D3Z099
swissprot - D3YWR7
Ensembl - ENSMUSG00000015806
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 qdprb1ENSDARG00000037378Danio rerio
 qdprb2ENSDARG00000086859Danio rerio
 qdprb2ENSDARG00000090118Danio rerio
 zgc:171517ENSDARG00000090822Danio rerio
 QDPRENSGALG00000030070Gallus gallus
 QDPRENSG00000151552Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006559 L-phenylalanine catabolic process IEA
 biological_processGO:0006729 tetrahydrobiopterin biosynthetic process ISS
 biological_processGO:0010044 response to aluminum ion IEA
 biological_processGO:0010288 response to lead ion IEA
 biological_processGO:0033762 response to glucagon IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0004155 6,7-dihydropteridine reductase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0070402 NADPH binding IEA
 molecular_functionGO:0070404 NADH binding IEA


Pathways (from Reactome)
Pathway description
Phenylalanine and tyrosine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch,Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J * SJL

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch,Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J * SJL

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor/J

 MP:0004678 split xiphoid process "the appearance of an abnormal division of the posterior tip of the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Qdprtm1Jcs/Qdpr+,Tapt1L5Jcs1/Tapt1+
Genetic Background: involves: 101/H * 129S4/SvJae * C3H/HeH * C3HeB/FeJ * C57BL/6J

 MP:0005321 abnormal neopterin level "anomalous concentration of this pteridine derivative, which is present in body fluids and is a precursor in the biosynthesis of biopterin; elevated levels result from immune activation, malignant disease, allograft rejection, and viral infection" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84533]
Show

Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch,Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J * SJL

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Qdprtm1Jcs/Qdpr+,Tapt1L5Jcs1/Tapt1+
Genetic Background: involves: 101/H * 129S4/SvJae * C3H/HeH * C3HeB/FeJ * C57BL/6J

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch,Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J * SJL

 MP:0012335 increased circulating homocysteine level "greater amount in the blood of sulfur-containing alpha-amino acid found in the plasma; blood levels are regulated by folic acid, vitamin B6 and vitamin B12" [MGI:csmith]
Show

Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch,Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015806 Qdpr / Q8BVI4 / quinoid dihydropteridine reductase / P09417*  / complex






 

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