ENSMUSG00000016308


Mus musculus

Features
Gene ID: ENSMUSG00000016308
  
Biological name :Ube2a
  
Synonyms : Q9Z255 / Ube2a / ubiquitin-conjugating enzyme E2A
  
Possible biological names infered from orthology : P49459
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A3.3
Gene start: 36873900
Gene end: 36884222
  
Corresponding Affymetrix probe sets: 10599222 (MoGene1.0st)   1417609_at (Mouse Genome 430 2.0 Array)   1448772_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143836
Ensembl peptide - ENSMUSP00000144372
Ensembl peptide - ENSMUSP00000144306
Ensembl peptide - ENSMUSP00000144262
Ensembl peptide - ENSMUSP00000144242
Ensembl peptide - ENSMUSP00000016452
NCBI entrez gene - 22209     See in Manteia.
MGI - MGI:102959
RefSeq - NM_001313696
RefSeq - NM_019668
RefSeq Peptide - NP_001300625
RefSeq Peptide - NP_062642
swissprot - Q3UCS1
swissprot - A0A0J9YUW6
swissprot - Q9Z255
swissprot - A0A0J9YUR7
swissprot - A0A0J9YUN2
swissprot - A0A0J9YTT1
swissprot - Q3TQ27
Ensembl - ENSMUSG00000016308
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ube2aENSDARG00000098466Danio rerio
 UBE2AENSGALG00000008648Gallus gallus
 UBE2AENSG00000077721Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ube2b / P63147 / ubiquitin-conjugating enzyme E2B / P63146*ENSMUSG0000002039095
Ube2u / ubiquitin-conjugating enzyme E2U (putative) / Q5VVX9*ENSMUSG0000006973332


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IBA
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0006281 DNA repair ISO
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0016567 protein ubiquitination IDA
 biological_processGO:0016574 histone ubiquitination IBA
 biological_processGO:0033522 histone H2A ubiquitination IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0051865 protein autoubiquitination IEA
 biological_processGO:0060135 maternal process involved in female pregnancy IMP
 biological_processGO:0070936 protein K48-linked ubiquitination IEA
 biological_processGO:0070979 protein K11-linked ubiquitination IEA
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0001741 XY body IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0033503 HULC complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ube2atm1Agr/Y,Ube2btm1Jhjh/Ube2b+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Ube2atm1Agr/Ube2atm1Agr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Ube2atm1Agr/Ube2atm1Agr,Ube2btm1Jhjh/Ube2b+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Ube2atm1Agr/Ube2atm1Agr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Ube2atm1Agr/Y,Ube2btm1Jhjh/Ube2b+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ube2atm1Agr/Y,Ube2btm1Jhjh/Ube2b+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Ube2atm1Agr/Ube2atm1Agr,Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Ube2atm1Agr/Ube2a+,Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Ube2atm1Agr/Ube2atm1Agr,Ube2btm1Jhjh/Ube2b+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
Show

Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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