ENSMUSG00000016349


Mus musculus

Features
Gene ID: ENSMUSG00000016349
  
Biological name :Eef1a2
  
Synonyms : Eef1a2 / Elongation factor 1-alpha 2 / P62631
  
Possible biological names infered from orthology : eukaryotic translation elongation factor 1 alpha 2 / Q05639
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H4
Gene start: 181147653
Gene end: 181157014
  
Corresponding Affymetrix probe sets: 10490602 (MoGene1.0st)   1418062_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054556
NCBI entrez gene - 13628     See in Manteia.
MGI - MGI:1096317
RefSeq - NM_007906
RefSeq Peptide - NP_031932
swissprot - P62631
Ensembl - ENSMUSG00000016349
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eef1a2ENSDARG00000006838Danio rerio
 EEF1A2ENSGALG00000005843Gallus gallus
 EEF1A2ENSG00000101210Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eef1a1 / P10126 / Elongation factor 1-alpha 1 / P68104* / eukaryotic translation elongation factor 1 alpha 1*ENSMUSG0000003774292


Protein motifs (from Interpro)
Interpro ID Name
 IPR000795  Transcription factor, GTP-binding domain
 IPR004160  Translation elongation factor EFTu/EF1A, C-terminal
 IPR004161  Translation elongation factor EFTu-like, domain 2
 IPR004539  Translation elongation factor EF1A, eukaryotic/archaeal
 IPR009000  Translation protein, beta-barrel domain superfamily
 IPR009001  Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031157  Tr-type G domain, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006414 translational elongation IDA
 biological_processGO:0010035 response to inorganic substance IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0090218 positive regulation of lipid kinase activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005853 eukaryotic translation elongation factor 1 complex IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003746 translation elongation factor activity IDA
 molecular_functionGO:0003924 GTPase activity IBA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Relnrl-Alb2/Relnrl-Alb2
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Relnrl-Alb2/Relnrl-Alb2
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Relnrl-Alb2/Relnrl-Alb2
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Vac14Gt(RRP155)Byg/Vac14ingls
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vac14Gt(RRP155)Byg/Vac14ingls
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
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Allelic Composition: Vac14Gt(RRP155)Byg/Vac14ingls
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Vac14Gt(RRP155)Byg/Vac14ingls
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Relnrl-Alb2/Relnrl-Alb2
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Vac14Gt(RRP155)Byg/Vac14ingls
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Relnrl-Alb2/Relnrl-Alb2
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Relnrl-Alb2/Relnrl-Alb2
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vac14Gt(RRP155)Byg/Vac14ingls
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vac14Gt(RRP155)Byg/Vac14ingls
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Relnrl-Alb2/Relnrl-Alb2
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002223 lymphoid hypoplasia "decreased cell number in lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Relnrl-Alb2/Relnrl-Alb2
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002914 abnormal endplate potential activity "defect in the excitatory response of peripheral synapses to stimulation; these amplitudes are larger than central synapse potentials" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Vac14Gt(RRP155)Byg/Vac14ingls
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0003444 abnormal neurotransmitter uptake "aberration in the reabsorbtion of endogenous signaling molecules normally taken in by neurons that alter the behavior of neurons or effector cells" [J:95639, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Vac14Gt(RRP155)Byg/Vac14ingls
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pthlhtm2Ack/Pthlhtm2Ack
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vac14Gt(RRP155)Byg/Vac14ingls
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Relnrl-Alb2/Relnrl-Alb2
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Relnrl-Alb2/Relnrl-Alb2
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005112 abnormal anterior horn morphology "anomalous structure of the ventral gray column of the spinal cord" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vac14Gt(RRP155)Byg/Vac14ingls
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Relnrl-Alb2/Relnrl-Alb2
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Relnrl-Alb2/Relnrl-Alb2
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Relnrl-Alb2/Relnrl-Alb2
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
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Allelic Composition: Relnrl-Alb2/Relnrl-Alb2
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0009434 paraparesis "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Relnrl-Alb2/Relnrl-Alb2
Genetic Background: involves: C3H/HeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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