ENSMUSG00000037742


Mus musculus

Features
Gene ID: ENSMUSG00000037742
  
Biological name :Eef1a1
  
Synonyms : Eef1a1 / Elongation factor 1-alpha 1 / P10126
  
Possible biological names infered from orthology : eukaryotic translation elongation factor 1 alpha 1 / P68104
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E1
Gene start: 78478449
Gene end: 78489151
  
Corresponding Affymetrix probe sets: 10448182 (MoGene1.0st)   10595183 (MoGene1.0st)   1424635_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042457
Ensembl peptide - ENSMUSP00000120438
Ensembl peptide - ENSMUSP00000116821
NCBI entrez gene - 13627     See in Manteia.
MGI - MGI:1096881
RefSeq - NM_010106
RefSeq Peptide - NP_034236
swissprot - D3YZ68
swissprot - D3Z3I8
swissprot - P10126
swissprot - Q58E64
Ensembl - ENSMUSG00000037742
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eef1a1aENSDARG00000039502Danio rerio
 eef1a1bENSDARG00000069951Danio rerio
 EEF1A1ENSGALG00000015917Gallus gallus
 EEF1A1ENSG00000156508Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eef1a2 / P62631 / Elongation factor 1-alpha 2 / Q05639* / eukaryotic translation elongation factor 1 alpha 2*ENSMUSG0000001634992


Protein motifs (from Interpro)
Interpro ID Name
 IPR000795  Transcription factor, GTP-binding domain
 IPR004160  Translation elongation factor EFTu/EF1A, C-terminal
 IPR004161  Translation elongation factor EFTu-like, domain 2
 IPR004539  Translation elongation factor EF1A, eukaryotic/archaeal
 IPR009000  Translation protein, beta-barrel domain superfamily
 IPR009001  Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031157  Tr-type G domain, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006414 translational elongation IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0000049 tRNA binding IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003746 translation elongation factor activity IBA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IDA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
HSF1 activation
Neutrophil degranulation
Protein methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1r+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1rtm2Arge,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mecp2tm1.1Bird/Y,Tg(MECP2*G273X/GFP)#Hzo/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Ccm2tm1Etl Tg(Tek-cre)1Ywa

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2Iaai/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1r+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1rtm2Arge,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbxw7tm1Iaai/Fbxw7tm1Iaai,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0010336 increased acute lymphoblastic leukemia incidence 
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Allelic Composition: Mecp2tm1.1Bird/Y,Tg(MECP2*G273X/GFP)#Hzo/0
Genetic Background: involves: 129P2/OlaHsd * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021951 Eef1akmt1 / EEF1A lysine methyltransferase 1 / Q8WVE0*  / reaction






 

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