ENSG00000156508


Homo sapiens

Features
Gene ID: ENSG00000156508
  
Biological name :EEF1A1
  
Synonyms : EEF1A1 / eukaryotic translation elongation factor 1 alpha 1 / P68104
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q13
Gene start: 73515750
Gene end: 73523797
  
Corresponding Affymetrix probe sets: 1557120_at (Human Genome U133 Plus 2.0 Array)   204892_x_at (Human Genome U133 Plus 2.0 Array)   206559_x_at (Human Genome U133 Plus 2.0 Array)   213477_x_at (Human Genome U133 Plus 2.0 Array)   213583_x_at (Human Genome U133 Plus 2.0 Array)   213614_x_at (Human Genome U133 Plus 2.0 Array)   227708_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000339063
Ensembl peptide - ENSP00000348651
Ensembl peptide - ENSP00000479609
Ensembl peptide - ENSP00000479055
Ensembl peptide - ENSP00000392366
Ensembl peptide - ENSP00000330054
Ensembl peptide - ENSP00000339053
NCBI entrez gene - 1915     See in Manteia.
OMIM - 130590
RefSeq - NM_001402
RefSeq - XM_011535514
RefSeq Peptide - NP_001393
swissprot - A0A087WV01
swissprot - A6PW80
swissprot - P68104
swissprot - Q5JR01
swissprot - Q6IPS9
swissprot - A0A087WVQ9
Ensembl - ENSG00000156508
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eef1a1aENSDARG00000039502Danio rerio
 eef1a1bENSDARG00000069951Danio rerio
 EEF1A1ENSGALG00000015917Gallus gallus
 Eef1a1ENSMUSG00000037742Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EEF1A2 / Q05639 / eukaryotic translation elongation factor 1 alpha 2ENSG0000010121093


Protein motifs (from Interpro)
Interpro ID Name
 IPR000795  Transcription factor, GTP-binding domain
 IPR004160  Translation elongation factor EFTu/EF1A, C-terminal
 IPR004161  Translation elongation factor EFTu-like, domain 2
 IPR004539  Translation elongation factor EF1A, eukaryotic/archaeal
 IPR009000  Translation protein, beta-barrel domain superfamily
 IPR009001  Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031157  Tr-type G domain, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006414 translational elongation IEA
 biological_processGO:0006479 protein methylation TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IDA
 biological_processGO:1904714 regulation of chaperone-mediated autophagy NAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005853 eukaryotic translation elongation factor 1 complex TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IDA
 cellular_componentGO:0032587 ruffle membrane IDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0098574 cytoplasmic side of lysosomal membrane NAS
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0000049 tRNA binding IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003746 translation elongation factor activity IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
Eukaryotic Translation Elongation
Peptide chain elongation
HSF1 activation
Neutrophil degranulation
Protein methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000114942 EEF1B2 / P24534 / eukaryotic translation elongation factor 1 beta 2  / reaction
 ENSG00000167658 EEF2 / P13639 / eukaryotic translation elongation factor 2  / reaction
 ENSG00000156508 EEF1A1 / P68104 / eukaryotic translation elongation factor 1 alpha 1  / reaction
 ENSG00000254772 EEF1G / P26641 / eukaryotic translation elongation factor 1 gamma  / reaction
 ENSG00000104529 EEF1D / P29692 / eukaryotic translation elongation factor 1 delta  / reaction
 ENSG00000203791 Q5JPI9 / EEF1AKMT2 / EEF1A lysine methyltransferase 2  / reaction
 ENSG00000150456 Q8WVE0 / EEF1AKMT1 / EEF1A lysine methyltransferase 1  / reaction






 

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