ENSMUSG00000016409


Mus musculus

Features
Gene ID: ENSMUSG00000016409
  
Biological name :Nkap
  
Synonyms : NF-kappa-B-activating protein / Nkap / Q9D0F4
  
Possible biological names infered from orthology : NFKB activating protein / Q8N5F7
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A3.3
Gene start: 37126795
Gene end: 37150746
  
Corresponding Affymetrix probe sets: 10599232 (MoGene1.0st)   1419763_at (Mouse Genome 430 2.0 Array)   1435662_at (Mouse Genome 430 2.0 Array)   1449589_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000016553
NCBI entrez gene - 67050     See in Manteia.
MGI - MGI:1914300
RefSeq - NM_025937
RefSeq Peptide - NP_080213
swissprot - Q9D0F4
Ensembl - ENSMUSG00000016409
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nkapENSDARG00000033450Danio rerio
 NKAPENSGALG00000020262Gallus gallus
 NKAPENSG00000101882Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nkapl / Q5SZT7 / NKAP-like protein / Q5M9Q1* / NFKB activating protein like*ENSMUSG0000005939559


Protein motifs (from Interpro)
Interpro ID Name
 IPR009269  NF-kappa-B-activating protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030851 granulocyte differentiation IMP
 biological_processGO:0033077 T cell differentiation in thymus IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0046638 positive regulation of alpha-beta T cell differentiation IEA
 biological_processGO:0071425 hematopoietic stem cell proliferation IMP
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0031490 chromatin DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Slc1a2tm1Kta/Slc1a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Slc1a2tm1Kta/Slc1a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc1a2tm1Kta/Slc1a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Slc1a2tm1Kta/Slc1a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc1a2tm1Kta/Slc1a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc1a2tm1Kta/Slc1a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010133 increased DN3 thymocyte number "increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]
Show

Allelic Composition: Slc1a2tm1Kta/Slc1a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010136 decreased DN4 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
Show

Allelic Composition: Slc1a2tm1Kta/Slc1a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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