ENSMUSG00000016494


Mus musculus

Features
Gene ID: ENSMUSG00000016494
  
Biological name :Cd34
  
Synonyms : Cd34 / Hematopoietic progenitor cell antigen CD34 / Q64314
  
Possible biological names infered from orthology : CD34 molecule / P28906
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H6
Gene start: 194938819
Gene end: 194961279
  
Corresponding Affymetrix probe sets: 10352905 (MoGene1.0st)   1416072_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000016638
Ensembl peptide - ENSMUSP00000106439
Ensembl peptide - ENSMUSP00000141884
NCBI entrez gene - 12490     See in Manteia.
MGI - MGI:88329
RefSeq - NM_001111059
RefSeq - NM_133654
RefSeq Peptide - NP_001104529
RefSeq Peptide - NP_598415
swissprot - Q64314
swissprot - Q543B6
swissprot - Q543Y2
swissprot - A0A0A6YX84
Ensembl - ENSMUSG00000016494
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000001177Gallus gallus
 CD34ENSG00000174059Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008083  CD34 antigen
 IPR013836  CD34/Podocalyxin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001894 tissue homeostasis ISS
 biological_processGO:0001935 endothelial cell proliferation ISO
 biological_processGO:0003094 glomerular filtration ISS
 biological_processGO:0003158 endothelium development IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008217 regulation of blood pressure ISS
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0030097 hemopoiesis ISO
 biological_processGO:0030195 negative regulation of blood coagulation ISS
 biological_processGO:0032720 negative regulation of tumor necrosis factor production ISS
 biological_processGO:0032733 positive regulation of interleukin-10 production ISS
 biological_processGO:0035759 mesangial cell-matrix adhesion ISS
 biological_processGO:0038001 paracrine signaling ISO
 biological_processGO:0042482 positive regulation of odontogenesis ISS
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process ISO
 biological_processGO:0045766 positive regulation of angiogenesis ISS
 biological_processGO:0048870 cell motility IEA
 biological_processGO:0050900 leukocyte migration IMP
 biological_processGO:0060290 transdifferentiation IEA
 biological_processGO:0061042 vascular wound healing IEA
 biological_processGO:0071425 hematopoietic stem cell proliferation ISO
 biological_processGO:0071636 positive regulation of transforming growth factor beta production ISS
 biological_processGO:0071657 positive regulation of granulocyte colony-stimulating factor production ISO
 biological_processGO:0071971 extracellular exosome assembly ISO
 biological_processGO:0072011 glomerular endothelium development IEA
 biological_processGO:0072089 stem cell proliferation IEA
 biological_processGO:0072254 metanephric glomerular mesangial cell differentiation IEA
 biological_processGO:0098609 cell-cell adhesion ISS
 biological_processGO:1900035 negative regulation of cellular response to heat ISO
 biological_processGO:1900038 negative regulation of cellular response to hypoxia ISO
 biological_processGO:1900041 negative regulation of interleukin-2 secretion ISO
 biological_processGO:1900168 positive regulation of glial cell-derived neurotrophic factor secretion ISO
 biological_processGO:1901215 negative regulation of neuron death ISS
 biological_processGO:2001214 positive regulation of vasculogenesis ISO
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005764 lysosome ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009897 external side of plasma membrane ISO
 cellular_componentGO:0009925 basal plasma membrane ISS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0036053 glomerular endothelium fenestra ISS
 cellular_componentGO:0045171 intercellular bridge ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0030246 carbohydrate binding ISO
 molecular_functionGO:0043199 sulfate binding IDA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dlg1tm1Taki/Dlg1tm1Taki
Genetic Background: involves: C57BL/6 * CBA

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Dlg1tm1Taki/Dlg1tm1Taki
Genetic Background: involves: C57BL/6 * CBA

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dlg1tm1Taki/Dlg1tm1Taki
Genetic Background: involves: C57BL/6 * CBA

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dlg1tm1Taki/Dlg1tm1Taki
Genetic Background: involves: C57BL/6 * CBA

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dlg1tm1Taki/Dlg1tm1Taki
Genetic Background: involves: C57BL/6 * CBA

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax1tm2Neu/Pax1tm2Neu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlg1tm1Taki/Dlg1tm1Taki
Genetic Background: involves: C57BL/6 * CBA

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dlg1tm1Taki/Dlg1tm1Taki
Genetic Background: involves: C57BL/6 * CBA

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax1tm2Neu/Pax1tm2Neu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlg1tm1Taki/Dlg1tm1Taki
Genetic Background: involves: C57BL/6 * CBA

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax1tm2Neu/Pax1tm2Neu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax1tm2Neu/Pax1tm2Neu
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026581 Sell / P18337 / selectin, lymphocyte / P14151* / selectin L*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr