ENSMUSG00000017210


Mus musculus

Features
Gene ID: ENSMUSG00000017210
  
Biological name :Med24
  
Synonyms : Med24 / Mediator of RNA polymerase II transcription subunit 24 / Q99K74
  
Possible biological names infered from orthology : mediator complex subunit 24 / O75448
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 98704591
Gene end: 98729435
  
Corresponding Affymetrix probe sets: 10390653 (MoGene1.0st)   1424180_a_at (Mouse Genome 430 2.0 Array)   1431282_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118820
Ensembl peptide - ENSMUSP00000120002
Ensembl peptide - ENSMUSP00000017354
Ensembl peptide - ENSMUSP00000098069
NCBI entrez gene - 23989     See in Manteia.
MGI - MGI:1344385
RefSeq - XM_006533302
RefSeq - XM_006533303
RefSeq - XM_006533304
RefSeq - XM_006533305
RefSeq - NM_011869
RefSeq Peptide - NP_035999
swissprot - Q99K74
swissprot - F6XX22
swissprot - A6PW46
swissprot - A6PW47
Ensembl - ENSMUSG00000017210
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 med24ENSDARG00000099431Danio rerio
 MED24ENSGALG00000013506Gallus gallus
 MED24ENSG00000008838Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR021429  Mediator complex, subunit Med24, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IMP
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter ISO
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0030518 intracellular steroid hormone receptor signaling pathway ISO
 biological_processGO:0030521 androgen receptor signaling pathway ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0051291 protein heterooligomerization IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016592 mediator complex IDA
 molecular_functionGO:0003712 transcription coregulator activity ISO
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0004402 histone acetyltransferase activity IEA
 molecular_functionGO:0046966 thyroid hormone receptor binding ISO
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Generic Transcription Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000279 ventricular hypoplasia "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Med24tm1Rgr/Med24tm1Rgr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Med24tm1Rgr/Med24tm1Rgr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
Show

Allelic Composition: Med24tm1Rgr/Med24tm1Rgr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Med24tm1Rgr/Med24tm1Rgr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Med24tm1Rgr/Med24tm1Rgr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Med24tm1Rgr/Med24tm1Rgr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Med24tm1Rgr/Med24tm1Rgr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Med24tm1Rgr/Med24tm1Rgr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0002740 heart hypoplasia "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]
Show

Allelic Composition: Med24tm1Rgr/Med24tm1Rgr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0004085 abnormal heartbeat "anomaly in the appearance of regularly spaced contractions of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Med24tm1Rgr/Med24tm1Rgr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Med24tm1Rgr/Med24tm1Rgr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Med24tm1Rgr/Med24tm1Rgr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Med24tm1Rgr/Med24tm1Rgr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Med24tm1Rgr/Med24tm1Rgr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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