ENSMUSG00000017446


Mus musculus

Features
Gene ID: ENSMUSG00000017446
  
Biological name :C1qtnf1
  
Synonyms : C1qtnf1 / Complement C1q tumor necrosis factor-related protein 1 / Q9QXP7
  
Possible biological names infered from orthology : C1q and TNF related 1 / Q9BXJ1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 118428203
Gene end: 118449963
  
Corresponding Affymetrix probe sets: 10383025 (MoGene1.0st)   1448912_at (Mouse Genome 430 2.0 Array)   1455582_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122759
Ensembl peptide - ENSMUSP00000017590
Ensembl peptide - ENSMUSP00000101893
Ensembl peptide - ENSMUSP00000117467
NCBI entrez gene - 56745     See in Manteia.
MGI - MGI:1919254
RefSeq - XM_006533822
RefSeq - NM_001204129
RefSeq - NM_001204130
RefSeq - NM_019959
RefSeq - XM_006533820
RefSeq - XM_006533821
RefSeq Peptide - NP_001191059
RefSeq Peptide - NP_064343
RefSeq Peptide - NP_001191058
swissprot - A2A4W2
swissprot - Q9QXP7
swissprot - A2A4W1
Ensembl - ENSMUSG00000017446
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 c1qtnf1ENSDARG00000088878Danio rerio
 Q9BXJ1ENSG00000173918Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6IR41 / C1qtnf6 / Complement C1q tumor necrosis factor-related protein 6 / Q9BXI9* / C1q and TNF related 6*ENSMUSG0000002244047
Q8R066 / C1qtnf4 / Complement C1q tumor necrosis factor-related protein 4 / Q9BXJ3* / C1q and TNF related 4*ENSMUSG0000004079423
C1qa / P98086 / Complement C1q subcomponent subunit A / P02745* / complement C1q A chain*ENSMUSG0000003688720


Protein motifs (from Interpro)
Interpro ID Name
 IPR001073  C1q domain
 IPR008160  Collagen triple helix repeat
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISO
 biological_processGO:0010544 negative regulation of platelet activation ISO
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010906 regulation of glucose metabolic process IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0070208 protein heterotrimerization IPI
 biological_processGO:0090331 negative regulation of platelet aggregation ISO
 biological_processGO:2000860 positive regulation of aldosterone secretion ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005518 collagen binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: B6N.129-Cnptm1(cre)Kan Ptentm1Hwu

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: B6N.129-Cnptm1(cre)Kan Ptentm1Hwu

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: B6N.129-Cnptm1(cre)Kan Ptentm1Hwu

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: B6N.129-Cnptm1(cre)Kan Ptentm1Hwu

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: B6N.129-Cnptm1(cre)Kan Ptentm1Hwu

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: B6N.129-Cnptm1(cre)Kan Ptentm1Hwu

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: B6N.129-Cnptm1(cre)Kan Ptentm1Hwu

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: B6N.129-Cnptm1(cre)Kan Ptentm1Hwu

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: B6N.129-Cnptm1(cre)Kan Ptentm1Hwu

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: B6N.129-Cnptm1(cre)Kan Ptentm1Hwu

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: B6N.129-Cnptm1(cre)Kan Ptentm1Hwu

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: B6N.129-Cnptm1(cre)Kan Ptentm1Hwu

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: B6N.129-Cnptm1(cre)Kan Ptentm1Hwu

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: B6N.129-Cnptm1(cre)Kan Ptentm1Hwu

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: B6N.129-Cnptm1(cre)Kan Ptentm1Hwu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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