ENSMUSG00000017697


Mus musculus

Features
Gene ID: ENSMUSG00000017697
  
Biological name :Ada
  
Synonyms : Ada / Adenosine deaminase / P03958
  
Possible biological names infered from orthology : P00813
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H3
Gene start: 163726584
Gene end: 163750239
  
Corresponding Affymetrix probe sets: 10489391 (MoGene1.0st)   1417976_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000017841
NCBI entrez gene - 11486     See in Manteia.
MGI - MGI:87916
RefSeq - NM_007398
RefSeq - NM_001272052
RefSeq Peptide - NP_001258981
RefSeq Peptide - NP_031424
swissprot - P03958
swissprot - Q4FK28
Ensembl - ENSMUSG00000017697
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adaENSDARG00000003113Danio rerio
 ADAENSGALG00000004170Gallus gallus
 ADAENSG00000196839Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001365  Adenosine/AMP deaminase domain
 IPR006330  Adenosine/adenine deaminase
 IPR006650  Adenosine/AMP deaminase active site
 IPR028893  Adenosine deaminase
 IPR032466  Metal-dependent hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001821 histamine secretion IEA
 biological_processGO:0001829 trophectodermal cell differentiation IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0002314 germinal center B cell differentiation IMP
 biological_processGO:0002636 positive regulation of germinal center formation IMP
 biological_processGO:0002686 negative regulation of leukocyte migration IMP
 biological_processGO:0002906 negative regulation of mature B cell apoptotic process IMP
 biological_processGO:0006154 adenosine catabolic process IEA
 biological_processGO:0006157 deoxyadenosine catabolic process IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009117 nucleotide metabolic process IEA
 biological_processGO:0009168 purine ribonucleoside monophosphate biosynthetic process IEA
 biological_processGO:0010460 positive regulation of heart rate IMP
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030890 positive regulation of B cell proliferation IMP
 biological_processGO:0032261 purine nucleotide salvage IEA
 biological_processGO:0033089 positive regulation of T cell differentiation in thymus IMP
 biological_processGO:0033197 response to vitamin E IEA
 biological_processGO:0033632 regulation of cell-cell adhesion mediated by integrin IEA
 biological_processGO:0042110 T cell activation IEA
 biological_processGO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043103 hypoxanthine salvage IBA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0045187 regulation of circadian sleep/wake cycle, sleep IEA
 biological_processGO:0045580 regulation of T cell differentiation IMP
 biological_processGO:0045582 positive regulation of T cell differentiation IMP
 biological_processGO:0045987 positive regulation of smooth muscle contraction IMP
 biological_processGO:0046061 dATP catabolic process IMP
 biological_processGO:0046085 adenosine metabolic process IEA
 biological_processGO:0046101 hypoxanthine biosynthetic process IMP
 biological_processGO:0046103 inosine biosynthetic process IEA
 biological_processGO:0046111 xanthine biosynthetic process IMP
 biological_processGO:0046638 positive regulation of alpha-beta T cell differentiation IMP
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0048541 Peyer"s patch development IMP
 biological_processGO:0048566 embryonic digestive tract development IMP
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IMP
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway IMP
 biological_processGO:0050870 positive regulation of T cell activation IMP
 biological_processGO:0060169 negative regulation of adenosine receptor signaling pathway IEA
 biological_processGO:0060407 negative regulation of penile erection IMP
 biological_processGO:0070244 negative regulation of thymocyte apoptotic process IMP
 biological_processGO:0070256 negative regulation of mucus secretion IMP
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0060205 cytoplasmic vesicle lumen IEA
 molecular_functionGO:0001883 purine nucleoside binding IEA
 molecular_functionGO:0004000 adenosine deaminase activity ISO
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019239 deaminase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Purine salvage


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Adatm1Mw/Adatm1Mw,Tg(Afp-ADA)#Xiay/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Adatm1Vlr/Adatm1Vlr
Genetic Background: either: 129P2/OlaHsd-Adatm1Vlr or (involves: (129P2/OlaHsd * FVB/N)

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0000606 decreased hepatocyte number "fewer than normal number of parenchymal liver cells" [J:23170]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0001379 abnormal penile erection function "altered ability to achieve a rigid and elevated state of the penis when the erectile tissue becomes filled with blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

Allelic Composition: Adatm1Vlr/Adatm1Vlr
Genetic Background: either: 129P2/OlaHsd-Adatm1Vlr or (involves: (129P2/OlaHsd * FVB/N)

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

Allelic Composition: Adatm1Vlr/Adatm1Vlr
Genetic Background: either: 129P2/OlaHsd-Adatm1Vlr or (involves: (129P2/OlaHsd * FVB/N)

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

Allelic Composition: Adatm1Mw/Adatm1Mw,Tg(Afp-ADA)#Xiay/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

Allelic Composition: Adatm1Mw/Adatm1Mw,Adora2btm1Dgen/Adora2btm1Dgen,Tg(Afp-ADA)#Xiay/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ubr2tm1Ytkw/Ubr2tm1Ytkw
Genetic Background: involves: 129S1/Sv

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0002336 abnormal pulmonary gas exchange "anomaly in the exchange of oxygen and carbon dioxide between the alveolar air and pulmonary capillary blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Adatm1Mw/Adatm1Mw,Tg(Afp-ADA)#Xiay/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

 MP:0002975 vascular smooth muscle hypertrophy "increase in size or thickness of the smooth muscle of the vascular wall" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

Allelic Composition: Adatm1Mw/Adatm1Mw,Tg(Afp-ADA)#Xiay/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

 MP:0003415 priapism "prolonged penile erection, often painful and without sexual desire " [smb:Susan M Bello, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0003548 pulmonary hypertension "sustained high pulmonary pressure at a level that is likely to result in disease and/or other pathological states" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54986]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

Allelic Composition: Adatm1Mw/Adatm1Mw,Tg(Afp-ADA)#Xiay/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

 MP:0003806 abnormal nucleotide metabolism "impaired regulation of nucleotide levels in either production or breakdown of these structural components of nucleic acids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

Allelic Composition: Adatm1Mw/Adatm1Mw,Tg(Afp-ADA)#Xiay/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

 MP:0004921 decreased placenta weight "reduction in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

Allelic Composition: Adatm1Mw/Adatm1Mw,Tg(Afp-ADA)#Xiay/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Adatm1Mw/Adatm1Mw,Tg(Afp-ADA)#Xiay/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

 MP:0005415 intrahepatic cholestasis "impariment of bile flow due to injury to the hepatocytes, bile canaliculi, or the intrahepatic bile ducts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Adatm1Vlr/Adatm1Vlr
Genetic Background: either: 129P2/OlaHsd-Adatm1Vlr or (involves: (129P2/OlaHsd * FVB/N)

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005426 tachypnea "rapid breathing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adatm1Mw/Adatm1Mw,Tg(Afp-ADA)#Xiay/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0010758 increased right ventricle systolic pressure "increase in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

 MP:0010896 decreased lung compliance "reduced ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

 MP:0010899 abnormal pulmonary alveolar system morphology 
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

 MP:0010935 increased airway resistance "greater opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MGI:csmith]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

 MP:0011044 increased lung elastance "faster ability of the lung to recoil toward its resting dimensions upon removal of pressure without disruption, usually expressed as the unit volume of change in the lung per unit of decreased pressure change; the reciprocal of compliance" [MGI:anna]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Adatm1Mw/Adatm1Mw,Tg(Afp-ADA)#Xiay/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Adatm1Vlr/Adatm1Vlr
Genetic Background: either: 129P2/OlaHsd-Adatm1Vlr or (involves: (129P2/OlaHsd * FVB/N)

 MP:0020427 increased hepatocyte karyomegaly "an increase in the number or proportion of liver cells with enlarged nuclei" [PMID:22733568, PMID:26980189, PMID:7731963, PMID:8701981, url:http://medical-dictionary.thefreedictionary.com/karyomegaly]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr