ENSMUSG00000017978


Mus musculus

Features
Gene ID: ENSMUSG00000017978
  
Biological name :Cadps2
  
Synonyms : Cadps2 / Calcium-dependent secretion activator 2 / Q8BYR5
  
Possible biological names infered from orthology : Q86UW7
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A3.1
Gene start: 23262773
Gene end: 23839421
  
Corresponding Affymetrix probe sets: 10543369 (MoGene1.0st)   1451499_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115866
Ensembl peptide - ENSMUSP00000111018
Ensembl peptide - ENSMUSP00000125972
Ensembl peptide - ENSMUSP00000138167
Ensembl peptide - ENSMUSP00000128905
Ensembl peptide - ENSMUSP00000018122
Ensembl peptide - ENSMUSP00000064876
Ensembl peptide - ENSMUSP00000111013
Ensembl peptide - ENSMUSP00000111015
NCBI entrez gene - 320405     See in Manteia.
MGI - MGI:2443963
RefSeq - XM_017321641
RefSeq - NM_001252110
RefSeq - NM_153163
RefSeq - XM_006505107
RefSeq - XM_006505108
RefSeq - XM_006505109
RefSeq - XM_006505110
RefSeq - XM_006505111
RefSeq - XM_006505112
RefSeq - XM_006505113
RefSeq - XM_006505114
RefSeq - XM_006505115
RefSeq - XM_017321639
RefSeq - XM_017321640
RefSeq - NM_001252105
RefSeq - NM_001252106
RefSeq - NM_001252107
RefSeq - NM_001252108
RefSeq Peptide - NP_001239036
RefSeq Peptide - NP_001239037
RefSeq Peptide - NP_001239039
RefSeq Peptide - NP_694803
RefSeq Peptide - NP_001239034
RefSeq Peptide - NP_001239035
swissprot - E9Q835
swissprot - Q8BYR5
swissprot - E9Q5C0
swissprot - F6SH36
swissprot - A4PI81
swissprot - S4R1C6
swissprot - A0A0M3HEP6
Ensembl - ENSMUSG00000017978
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CADPS2ENSGALG00000008926Gallus gallus
 CADPS2ENSG00000081803Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cadps / Q80TJ1 / Calcium-dependent secretion activator 1 / Q9ULU8* / calcium dependent secretion activator*ENSMUSG0000005442376


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR010439  Calcium-dependent secretion activator domain
 IPR011993  PH-like domain superfamily
 IPR014770  Munc13 homology 1
 IPR033227  Calcium-dependent secretion activator
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0009267 cellular response to starvation IEP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016079 synaptic vesicle exocytosis IEA
 biological_processGO:0016082 synaptic vesicle priming IGI
 biological_processGO:0045921 positive regulation of exocytosis IDA
 biological_processGO:1990504 dense core granule exocytosis IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0042734 presynaptic membrane IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

Allelic Composition: Cadps2tm1Tfr/Cadps2+
Genetic Background: C57BL/6-Cadps2tm1Tfr

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

Allelic Composition: Cadps2tm1Tfr/Cadps2+
Genetic Background: C57BL/6-Cadps2tm1Tfr

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0001739 abnormal adrenal secretion "altered ability of the surparenal gland to secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Cadpstm1Bros/Cadpstm1Bros,Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cadpstm1Bros/Cadpstm1Bros,Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0002710 increased glucagon secretion "greater than normal release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

Allelic Composition: Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Cadpstm1Bros/Cadpstm1Bros,Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

Allelic Composition: Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cadpstm1Bros/Cadpstm1Bros,Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0002918 abnormal paired-pulse facilitation "defects in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0002948 abnormal neuronal specification "defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:87948]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

Allelic Composition: Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0003172 abnormal lysosome physiology "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

Allelic Composition: Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cadpstm1Bros/Cadpstm1Bros,Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Cadpstm1Bros/Cadpstm1Bros,Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

Allelic Composition: Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0008953 abnormal pancreatic somatostatin secretion "anomaly in the production or release from pancreatic delta cells of a 14 amino acid peptide that inhibits growth hormone release and is found in the central and peripheral nervous systems, the gut, and other organs" [MESH:D06.472.699.327.700.875]
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Allelic Composition: Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0009267 abnormal cerebellum fissure morphology "any structural anomaly of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0009619 abnormal optokinetic reflex "any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the visual system by movement; normally, this reflex functions to stabilize a moving image on the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0009977 abnormal cerebellar granule cell migration "defective or impaired movement of cerebellar granule cell neurons from the germinal zone into the granule cell layer of the cerebellum during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cadpstm1Bros/Cadpstm1Bros,Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
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Allelic Composition: Slc35c1tm1Cknr/Slc35c1tm1Cknr
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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