ENSMUSG00000054423


Mus musculus

Features
Gene ID: ENSMUSG00000054423
  
Biological name :Cadps
  
Synonyms : Cadps / Calcium-dependent secretion activator 1 / Q80TJ1
  
Possible biological names infered from orthology : calcium dependent secretion activator / Q9ULU8
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: A1
Gene start: 12372563
Gene end: 12823079
  
Corresponding Affymetrix probe sets: 10417628 (MoGene1.0st)   1448955_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153426
Ensembl peptide - ENSMUSP00000136076
Ensembl peptide - ENSMUSP00000153630
Ensembl peptide - ENSMUSP00000064706
Ensembl peptide - ENSMUSP00000108276
Ensembl peptide - ENSMUSP00000108277
NCBI entrez gene - 27062     See in Manteia.
MGI - MGI:1350922
RefSeq - XM_017316038
RefSeq - XM_017316031
RefSeq - XM_017316032
RefSeq - XM_017316033
RefSeq - XM_017316034
RefSeq - XM_017316035
RefSeq - XM_017316036
RefSeq - XM_017316037
RefSeq - NM_001042617
RefSeq - NM_012061
RefSeq - XM_006518024
RefSeq - XM_006518025
RefSeq - XM_006518026
RefSeq - XM_006518027
RefSeq - XM_006518028
RefSeq - XM_006518029
RefSeq - XM_006518030
RefSeq - XM_006518031
RefSeq - XM_006518032
RefSeq - XM_006518033
RefSeq - XM_006518034
RefSeq - XM_006518035
RefSeq - XM_006518036
RefSeq - XM_006518039
RefSeq - XM_006518040
RefSeq - XM_006518041
RefSeq - XM_006518042
RefSeq - XM_006518043
RefSeq - XM_006518044
RefSeq - XM_006518045
RefSeq - XM_006518047
RefSeq - XM_006518048
RefSeq - XM_017316029
RefSeq - XM_017316030
RefSeq Peptide - NP_001036082
RefSeq Peptide - NP_036191
swissprot - A0A286YE00
swissprot - J3QJW3
swissprot - A0A286YDH6
swissprot - Q80TJ1
swissprot - K4DI76
Ensembl - ENSMUSG00000054423
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cadps2ENSDARG00000013312Danio rerio
 cadpsaENSDARG00000043661Danio rerio
 cadpsbENSDARG00000070567Danio rerio
 ENSGALG00000007268Gallus gallus
 ENSGALG00000035827Gallus gallus
 CADPSENSG00000163618Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cadps2 / Q8BYR5 / Calcium-dependent secretion activator 2 / Q86UW7*ENSMUSG0000001797873


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR010439  Calcium-dependent secretion activator domain
 IPR011993  PH-like domain superfamily
 IPR014770  Munc13 homology 1
 IPR033227  Calcium-dependent secretion activator
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016050 vesicle organization IMP
 biological_processGO:0016079 synaptic vesicle exocytosis IEA
 biological_processGO:0016082 synaptic vesicle priming IGI
 biological_processGO:0050432 catecholamine secretion IMP
 biological_processGO:0099525 presynaptic dense core vesicle exocytosis IGI
 biological_processGO:1990504 dense core granule exocytosis IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Sema6aGt(KST069)Byg/Sema6aGt(KST069)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Ito Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0001739 abnormal adrenal secretion "altered ability of the surparenal gland to secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myctm1Lbox/Myc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Cadpstm1Bros/Cadps+
Genetic Background: Not Specified

Allelic Composition: Cadpstm1Bros/Cadpstm1Bros,Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Myctm1Lbox/Myc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cadpstm1Bros/Cadpstm1Bros,Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0002710 increased glucagon secretion "greater than normal release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Myctm1Lbox/Myc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Cadpstm1Bros/Cadpstm1Bros,Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0002909 abnormal adrenal gland physiology "altered ability of the surparenal gland to produce and secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myctm1Lbox/Myc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Myctm1Lbox/Myc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Cadpstm1Bros/Cadpstm1Bros,Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0003172 abnormal lysosome physiology "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myctm1Lbox/Myc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Cadpstm1Bros/Cadpstm1Bros,Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Ito Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0004807 abnormal paired pulse inhibition "defects in the supressive response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of inhibition of neurotransmitter release at the second stimulus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Ito Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Myctm1Lbox/Myc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Cadpstm1Bros/Cadpstm1Bros,Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0008571 abnormal synaptic bouton morphology "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Ito Cadpstm1.1Tfr Cadpstm1.2Tfr

Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Ito Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Myctm1Lbox/Myc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Cadpstm1Bros/Cadpstm1Bros,Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
Show

Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0011743 abnormal Golgi apparatus morphology "any structural anomaly of the compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack; Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations" [GO:0005794, MGI:mberry]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Ito Cadpstm1.1Tfr Cadpstm1.2Tfr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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