ENSMUSG00000018377


Mus musculus

Features
Gene ID: ENSMUSG00000018377
  
Biological name :Vezf1
  
Synonyms : vascular endothelial zinc finger 1 / Vezf1
  
Possible biological names infered from orthology : Q14119
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 88068279
Gene end: 88084729
  
Corresponding Affymetrix probe sets: 10380219 (MoGene1.0st)   1429084_at (Mouse Genome 430 2.0 Array)   1429085_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018521
Ensembl peptide - ENSMUSP00000114394
NCBI entrez gene - 22344     See in Manteia.
MGI - MGI:1313291
RefSeq - XM_011248969
RefSeq - NM_016686
RefSeq - XM_011248968
RefSeq Peptide - NP_057895
swissprot - Q5SXC4
swissprot - Q5SXC3
Ensembl - ENSMUSG00000018377
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vezf1aENSDARG00000008247Danio rerio
 vezf1bENSDARG00000061030Danio rerio
 VEZF1ENSGALG00000005530Gallus gallus
 VEZF1ENSG00000136451Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Maz / MYC associated zinc finger protein / P56270*ENSMUSG0000003067830
Patz1 / POZ-, AT hook-, and zinc finger-containing protein 1 isoform 3 / Q9HBE1* / POZ/BTB and AT hook containing zinc finger 1*ENSMUSG0000002045326


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001885 endothelial cell development IMP
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0045603 positive regulation of endothelial cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003676 nucleic acid binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgavtm1Hyn/Itgavtm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0000265 atretic vasculature "absence or disorganization of vasculature" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571]
Show

Allelic Composition: Itgavtm1Hyn/Itgavtm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgavtm1Hyn/Itgavtm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Vezf1tm1Stmn/Vezf1+
Genetic Background: B6.129-Vezf1tm1Stmn

Allelic Composition: Vezf1tm1Stmn/Vezf1tm1Stmn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vezf1tm1Stmn/Vezf1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Itgavtm1Hyn/Itgavtm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Vezf1tm1Stmn/Vezf1+
Genetic Background: B6.129-Vezf1tm1Stmn

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Itgavtm1Hyn/Itgavtm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001699 enlarged embryo size "larger proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Vezf1tm1Stmn/Vezf1+
Genetic Background: B6.129-Vezf1tm1Stmn

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgavtm1Hyn/Itgavtm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Vezf1tm1Stmn/Vezf1tm1Stmn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002672 abnormal branchial arch artery morphology "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgavtm1Hyn/Itgavtm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
Show

Allelic Composition: Itgavtm1Hyn/Itgavtm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgavtm1Hyn/Itgavtm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Vezf1tm1Stmn/Vezf1tm1Stmn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Itgavtm1Hyn/Itgavtm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Vezf1tm1Stmn/Vezf1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Vezf1tm1Stmn/Vezf1+
Genetic Background: B6.129-Vezf1tm1Stmn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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