Manteia

ENSMUSG00000020453

Mus musculus

Features

Gene ID:	ENSMUSG00000020453

Biological name :	Patz1

Synonyms :	Patz1 / POZ-, AT hook-, and zinc finger-containing protein 1 isoform 3

Possible biological names infered from orthology :	POZ/BTB and AT hook containing zinc finger 1 / Q9HBE1

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	A1
Gene start:	3288874
Gene end:	3309083

Corresponding Affymetrix probe sets:	10373728 (MoGene1.0st) 1429739_a_at (Mouse Genome 430 2.0 Array) 1434495_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000050684 Ensembl peptide - ENSMUSP00000091103 Ensembl peptide - ENSMUSP00000122832 Ensembl peptide - ENSMUSP00000138522 Ensembl peptide - ENSMUSP00000092043 Ensembl peptide - ENSMUSP00000105670 NCBI entrez gene - 56218 See in Manteia. MGI - MGI:1891832 RefSeq - NM_019574 RefSeq - NM_001253690 RefSeq - NM_001253691 RefSeq Peptide - NP_001240619 RefSeq Peptide - NP_001240620 RefSeq Peptide - NP_062520 swissprot - Q5NBY8 swissprot - Q5NBY9 swissprot - Q5NBZ1 swissprot - Q5NBZ2 swissprot - Q7TNQ3 swissprot - Q9JMG9 Ensembl - ENSMUSG00000020453

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
patz1	ENSDARG00000076584	Danio rerio
PATZ1	ENSGALG00000006934	Gallus gallus
PATZ1	ENSG00000100105	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Maz / MYC associated zinc finger protein / P56270*	ENSMUSG00000030678	23
Vezf1 / vascular endothelial zinc finger 1 / Q14119*	ENSMUSG00000018377	21

Protein motifs (from Interpro)

Interpro ID	Name
IPR000210	BTB/POZ domain
IPR000637	HMG-I/HMG-Y, DNA-binding, conserved site
IPR011333	SKP1/BTB/POZ domain superfamily
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR013087	Zinc finger C2H2-type
IPR029037	YfgJ-like
IPR036236	Zinc finger C2H2 superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006355	regulation of transcription, DNA-templated	IPI
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0007283	spermatogenesis	IMP
biological_process	GO:0008584	male gonad development	IMP
biological_process	GO:0010468	regulation of gene expression	IDA
biological_process	GO:0010596	negative regulation of endothelial cell migration	IMP
biological_process	GO:0030217	T cell differentiation	IDA
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	ISS
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IDA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
cellular_component	GO:0005634	nucleus	ISS
cellular_component	GO:0005654	nucleoplasm	ISO
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IDA
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IDA
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003677	DNA binding	IDA
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000715	decreased thymocyte number	"fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000774	reduced brain size	"smaller appearance of the brain" [J:35802]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0000820	abnormal choroid plexus morphology	"malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0000830	abnormal diencephalon morphology	"any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0000841	abnormal hindbrain morphology	"malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0000914	exencephaly	"neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0000928	incomplete cephalic closure	"arrest of the fusion of the cephalic neural folds" [J:12622]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Gli3^Mos1/Gli3⁺,Sox10^tm1Weg/Sox10⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
MP:0001152	Leydig cell hyperplasia	"increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]	Show Allelic Composition: Gli3^Mos1/Gli3⁺,Sox10^tm1Weg/Sox10⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
MP:0001153	small seminiferous tubules	"reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: Gli3^Mos1/Gli3⁺,Sox10^tm1Weg/Sox10⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
MP:0001155	arrest of spermatogenesis	"block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]	Show Allelic Composition: Gli3^Mos1/Gli3⁺,Sox10^tm1Weg/Sox10⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Gli3^Mos1/Gli3⁺,Sox10^tm1Weg/Sox10⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Gli3^Mos1/Gli3⁺,Sox10^tm1Weg/Sox10⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
MP:0002080	prenatal lethality	"death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd8a^tm2.1Welm/Cd8a^tm2.1Welm Genetic Background: involves: 129P2/OlaHsd
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0002216	abnormal seminiferous tubule morphology	"malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gli3^Mos1/Gli3⁺,Sox10^tm1Weg/Sox10⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
MP:0002685	abnormal proliferation of spermatogonia	"reduction in the proliferation of the spermatogonial stem cells either due to reduced mitosis or increased apoptosis" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62271]	Show Allelic Composition: Gli3^Mos1/Gli3⁺,Sox10^tm1Weg/Sox10⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
MP:0003077	abnormal cell cycle	"failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0003944	abnormal T cell subpopulation ratio	"deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]	Show Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Patz1^tm1.1Welm/Patz1^tm1.1Welm,Tg(TcraTcrb)425Cbn/0 Genetic Background: involves: C57BL/6 Allelic Composition: Patz1^tm1.1Welm/Patz1^tm1.1Welm,Tg(TcraTcrb)1100Mjb/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004110	transposition of great arteries	"cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0004200	reduced fetal size	"smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0004261	abnormal embryonic neuroepithelium morphology	"any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0004274	abnormal embryonic/fetal subventricular zone morphology	"any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0004852	decreased testis weight	"reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gli3^Mos1/Gli3⁺,Sox10^tm1Weg/Sox10⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
MP:0005159	azoospermia	"absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gli3^Mos1/Gli3⁺,Sox10^tm1Weg/Sox10⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
MP:0005462	abnormal mast cell morphology/development	"anomalous structure, development or number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Atp1a3^tm1.1Kwk/Atp1a3⁺ Genetic Background: B6JJcl.Cg-Atp1a3^tm1.1Kwk
MP:0006126	abnormal outflow tract development	"anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0008008	early cellular replicative senescence	"increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0008074	increased CD4-positive T cell number	"greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Patz1^tm1.1Welm/Patz1^tm1.1Welm,Tg(TcraTcrb)425Cbn/0 Genetic Background: involves: C57BL/6 Allelic Composition: Patz1^tm1.1Welm/Patz1^tm1.1Welm,Tg(TcraTcrb)1100Mjb/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Patz1^tm1.1Welm/Patz1^tm1.1Welm,Tg(TcraTcrb)425Cbn/0 Genetic Background: involves: C57BL/6 Allelic Composition: Patz1^tm1.1Welm/Patz1^tm1.1Welm,Tg(TcraTcrb)1100Mjb/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008706	decreased interleukin-6 secretion	"reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Atp1a3^tm1.1Kwk/Atp1a3⁺ Genetic Background: B6JJcl.Cg-Atp1a3^tm1.1Kwk
MP:0009339	decreased splenocyte number	"reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009869	abnormal descending aorta morphology	"any strucutral anomaly of the part of the aorta extending from the arch of aorta to the point where it divides into the common iliac arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Orc1^{tm1a(KOMP)Wtsi}/Orc1^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Orc1^{tm1a(KOMP)Wtsi}/Wtsi
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0011380	enlarged brain ventricle	"increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0011703	increased fibroblast proliferation	"greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]	Show Allelic Composition: Shh^tm3(cre)Chg/Shh^tm3(cre)Chg Genetic Background: Not Specified
MP:0011704	decreased fibroblast proliferation	"reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr