ENSMUSG00000018398


Mus musculus

Features
Gene ID: ENSMUSG00000018398
  
Biological name :Sept8
  
Synonyms : Mus musculus septin 8 (Sept8), transcript variant 4, mRNA. / Q8CHH9 / Sept8
  
Possible biological names infered from orthology : Q92599 / septin 8
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 53519257
Gene end: 53549565
  
Corresponding Affymetrix probe sets: 10376021 (MoGene1.0st)   1426801_at (Mouse Genome 430 2.0 Array)   1426802_at (Mouse Genome 430 2.0 Array)   1456885_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113038
Ensembl peptide - ENSMUSP00000112920
Ensembl peptide - ENSMUSP00000113775
Ensembl peptide - ENSMUSP00000124057
Ensembl peptide - ENSMUSP00000120427
Ensembl peptide - ENSMUSP00000104615
NCBI entrez gene - 20362     See in Manteia.
MGI - MGI:894310
RefSeq - XM_017314394
RefSeq - NM_001347496
RefSeq - NM_033144
RefSeq - XM_006532633
RefSeq - XM_006532634
RefSeq - XM_006532635
RefSeq - XM_011248833
RefSeq - XM_011248834
RefSeq - XM_017314392
RefSeq - XM_017314393
RefSeq - NM_001252332
RefSeq - NM_001252333
RefSeq Peptide - NP_001239262
RefSeq Peptide - NP_001334425
RefSeq Peptide - NP_149156
RefSeq Peptide - NP_001239261
swissprot - E0CYM4
swissprot - Q8CHH9
swissprot - B7ZC46
swissprot - B1AQZ0
swissprot - B1AQY9
Ensembl - ENSMUSG00000018398
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SEPT8ENSG00000164402Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8C1B7 / Sept11 / septin 11 / Q9NVA2*ENSMUSG0000005801370
Sept6 / Q9R1T4 / Septin-6 / Q14141*ENSMUSG0000005037969
Sept10 / septin 10 / Q9P0V9*ENSMUSG0000001991764
Q9DA97 / Sept14 / Septin-14 / Q6ZU15*ENSMUSG0000003421953


Protein motifs (from Interpro)
Interpro ID Name
 IPR016491  Septin
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030379  Septin-type guanine nucleotide-binding (G) domain
 IPR030646  Septin 8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Sept8tm1c(EUCOMM)Wtsi/Sept8tm1c(EUCOMM)Wtsi
Genetic Background: B6N.Cg-Sept8tm1c(EUCOMM)Wtsi Cnptm1(cre)Kan

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Sept8tm1c(EUCOMM)Wtsi/Sept8tm1c(EUCOMM)Wtsi
Genetic Background: B6N.Cg-Sept8tm1c(EUCOMM)Wtsi Cnptm1(cre)Kan

Allelic Composition: Sept8tm1d(EUCOMM)Wtsi/Sept8tm1d(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Sept8tm1d(EUCOMM)Wtsi

 MP:0012674 tomacula "focal myelin swellings due to redundant folding of myelin sheaths; often sausage-shaped and excessively folded" [MGI:smb]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Sept8tm1c(EUCOMM)Wtsi/Sept8tm1c(EUCOMM)Wtsi
Genetic Background: B6N.Cg-Sept8tm1c(EUCOMM)Wtsi Cnptm1(cre)Kan

Allelic Composition: Sept8tm1c(EUCOMM)Wtsi/Sept8tm1c(EUCOMM)Wtsi,Tg(Plp1-cre/ERT2)1Ueli/0
Genetic Background: B6N.Cg-Sept8tm1c(EUCOMM)Wtsi Tg(Plp1-cre/ERT2)1Ueli

Allelic Composition: Sept8tm1d(EUCOMM)Wtsi/Sept8tm1d(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Sept8tm1d(EUCOMM)Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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