ENSMUSG00000018765


Mus musculus

Features
Gene ID: ENSMUSG00000018765
  
Biological name :Fxr2
  
Synonyms : FMR1 autosomal homolog 2 / Fxr2
  
Possible biological names infered from orthology : P51116
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 69632990
Gene end: 69653297
  
Corresponding Affymetrix probe sets: 10377569 (MoGene1.0st)   1422522_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018909
NCBI entrez gene - 23879     See in Manteia.
MGI - MGI:1346074
RefSeq - NM_011814
RefSeq Peptide - NP_035944
swissprot - Q6P5B5
Ensembl - ENSMUSG00000018765
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fxr2ENSDARG00000016260Danio rerio
 FXR2ENSG00000129245Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fxr1 / Q61584 / Fragile X mental retardation syndrome-related protein 1 / P51114* / FMR1 autosomal homolog 1*ENSMUSG0000002768064
Fmr1 / fragile X mental retardation 1 / Q06787*ENSMUSG0000000083845


Protein motifs (from Interpro)
Interpro ID Name
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR008395  Agenet-like domain
 IPR022034  Fragile X-related 1 protein, C-terminal core
 IPR032172  Fragile X-related 1 protein, C-terminal region 1
 IPR036612  K Homology domain, type 1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003460 decreased fear-related response "reduced emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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