ENSMUSG00000027680


Mus musculus

Features
Gene ID: ENSMUSG00000027680
  
Biological name :Fxr1
  
Synonyms : Fragile X mental retardation syndrome-related protein 1 / Fxr1 / Q61584
  
Possible biological names infered from orthology : FMR1 autosomal homolog 1 / P51114
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A3
Gene start: 34019943
Gene end: 34070322
  
Corresponding Affymetrix probe sets: 10491455 (MoGene1.0st)   1417598_a_at (Mouse Genome 430 2.0 Array)   1436400_at (Mouse Genome 430 2.0 Array)   1442059_at (Mouse Genome 430 2.0 Array)   1452247_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142441
Ensembl peptide - ENSMUSP00000142847
Ensembl peptide - ENSMUSP00000143614
Ensembl peptide - ENSMUSP00000143562
Ensembl peptide - ENSMUSP00000143392
Ensembl peptide - ENSMUSP00000001620
Ensembl peptide - ENSMUSP00000130216
NCBI entrez gene - 14359     See in Manteia.
MGI - MGI:104860
RefSeq - XM_006535400
RefSeq - XM_017319456
RefSeq - XM_006535402
RefSeq - XM_006535401
RefSeq - NM_001113188
RefSeq - NM_001113189
RefSeq - NM_008053
RefSeq Peptide - NP_001106659
RefSeq Peptide - NP_001106660
RefSeq Peptide - NP_032079
swissprot - Q61584
swissprot - A0A0H2UH27
swissprot - A0A0G2JEP0
swissprot - A0A0G2JGH0
swissprot - A0A0G2JGL6
Ensembl - ENSMUSG00000027680
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fxr1ENSDARG00000022968Danio rerio
 FXR1ENSGALG00000008864Gallus gallus
 FXR1ENSG00000114416Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fxr2 / FMR1 autosomal homolog 2 / P51116*ENSMUSG0000001876563
Fmr1 / fragile X mental retardation 1 / Q06787*ENSMUSG0000000083850


Protein motifs (from Interpro)
Interpro ID Name
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR008395  Agenet-like domain
 IPR022034  Fragile X-related 1 protein, C-terminal core
 IPR032172  Fragile X-related 1 protein, C-terminal region 1
 IPR032177  Fragile X-related 1 protein, C-terminal region 3
 IPR036612  K Homology domain, type 1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0017148 negative regulation of translation IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:2000637 positive regulation of gene silencing by miRNA ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005844 polysome IDA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0035770 ribonucleoprotein granule IDA
 cellular_componentGO:0043034 costamere IDA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0002151 G-quadruplex RNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0033592 RNA strand annealing activity ISO
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0046982 protein heterodimerization activity ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Fxr1tm1.2Dln/Fxr1tm1.2Dln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

Allelic Composition: Fxr1tm1.2Dln/Fxr1tm1.2Dln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
Show

Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fxr1tm1.2Dln/Fxr1tm1.2Dln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
Show

Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
Show

Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
Show

Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Fxr1tm1.2Dln/Fxr1tm1.2Dln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fxr1tm1Drad/Fxr1tm1Drad
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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