ENSMUSG00000019087


Mus musculus

Features
Gene ID: ENSMUSG00000019087
  
Biological name :Atp6ap1
  
Synonyms : Atp6ap1 / ATPase, H+ transporting, lysosomal accessory protein 1 / Q9R1Q9
  
Possible biological names infered from orthology : ATPase H+ transporting accessory protein 1 / Q15904
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A7.3
Gene start: 74297097
Gene end: 74304721
  
Corresponding Affymetrix probe sets: 10600377 (MoGene1.0st)   1449622_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117604
Ensembl peptide - ENSMUSP00000117006
Ensembl peptide - ENSMUSP00000118722
Ensembl peptide - ENSMUSP00000019231
Ensembl peptide - ENSMUSP00000109808
Ensembl peptide - ENSMUSP00000116162
Ensembl peptide - ENSMUSP00000116432
NCBI entrez gene - 54411     See in Manteia.
MGI - MGI:109629
RefSeq - XM_017318548
RefSeq - NM_001358380
RefSeq - NM_018794
RefSeq Peptide - NP_001345309
RefSeq Peptide - NP_061264
swissprot - Q9R1Q9
swissprot - B7FAU3
swissprot - Q3TKX1
swissprot - Q3TWN7
swissprot - F6X9J0
swissprot - F7AYP0
swissprot - F6ZE56
swissprot - B7FAU7
Ensembl - ENSMUSG00000019087
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp6ap1aENSDARG00000041417Danio rerio
 atp6ap1bENSDARG00000037153Danio rerio
 ATP6AP1ENSGALG00000008836Gallus gallus
 Q15904ENSG00000071553Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp6ap1l / ATPase, H+ transporting, lysosomal accessory protein 1-like / Q52LC2* / ATPase H+ transporting accessory protein 1 like*ENSMUSG0000007895817


Protein motifs (from Interpro)
Interpro ID Name
 IPR008388  ATPase, V1 complex, subunit S1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006879 cellular iron ion homeostasis IEA
 biological_processGO:0015991 ATP hydrolysis coupled proton transport IEA
 biological_processGO:0036295 cellular response to increased oxygen levels IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IMP
 biological_processGO:0045780 positive regulation of bone resorption IMP
 biological_processGO:0045851 pH reduction IMP
 biological_processGO:0045921 positive regulation of exocytosis IMP
 biological_processGO:0051656 establishment of organelle localization IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:2001206 positive regulation of osteoclast development IMP
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA
 cellular_componentGO:0033180 proton-transporting V-type ATPase, V1 domain IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IPI
 molecular_functionGO:0046933 proton-transporting ATP synthase activity, rotational mechanism IEA
 molecular_functionGO:0046961 proton-transporting ATPase activity, rotational mechanism IEA


Pathways (from Reactome)
Pathway description
Insulin receptor recycling
Transferrin endocytosis and recycling
Ion channel transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itpr3tf/Itpr3tf,Prkralear-5J/Prkralear-5J
Genetic Background: BTBR-Prkralear-5J Itpr3tf/GrsrJ

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itpr3tf/Itpr3tf,Prkralear-5J/Prkralear-5J
Genetic Background: BTBR-Prkralear-5J Itpr3tf/GrsrJ

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Itpr3tf/Itpr3tf,Prkralear-5J/Prkralear-5J
Genetic Background: BTBR-Prkralear-5J Itpr3tf/GrsrJ

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Itpr3tf/Itpr3tf,Prkralear-5J/Prkralear-5J
Genetic Background: BTBR-Prkralear-5J Itpr3tf/GrsrJ

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Itpr3tf/Itpr3tf,Prkralear-5J/Prkralear-5J
Genetic Background: BTBR-Prkralear-5J Itpr3tf/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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