ENSMUSG00000019428


Mus musculus

Features
Gene ID: ENSMUSG00000019428
  
Biological name :Fkbp8
  
Synonyms : Fkbp8 / O35465 / Peptidyl-prolyl cis-trans isomerase FKBP8
  
Possible biological names infered from orthology : FK506 binding protein 8 / Q14318
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 70527724
Gene end: 70535328
  
Corresponding Affymetrix probe sets: 10572408 (MoGene1.0st)   1416113_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112527
Ensembl peptide - ENSMUSP00000114069
Ensembl peptide - ENSMUSP00000118843
Ensembl peptide - ENSMUSP00000074935
Ensembl peptide - ENSMUSP00000113528
NCBI entrez gene - 14232     See in Manteia.
MGI - MGI:1341070
RefSeq - XM_017312568
RefSeq - NM_001199631
RefSeq - NM_010223
RefSeq - XM_006509556
RefSeq - XM_017312565
RefSeq - XM_017312566
RefSeq - XM_017312567
RefSeq - NM_001111066
RefSeq Peptide - NP_034353
RefSeq Peptide - NP_001104536
RefSeq Peptide - NP_001186560
swissprot - F6WP10
swissprot - O35465
swissprot - D3Z597
Ensembl - ENSMUSG00000019428
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fkbp8ENSDARG00000001734Danio rerio
 FKBP8ENSGALG00000003357Gallus gallus
 FKBP8ENSG00000105701Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fkbp6 / Q91XW8 / Inactive peptidyl-prolyl cis-trans isomerase FKBP6 / O75344* / FK506 binding protein 6*ENSMUSG0000004001320


Protein motifs (from Interpro)
Interpro ID Name
 IPR001179  FKBP-type peptidyl-prolyl cis-trans isomerase domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR023566  Peptidyl-prolyl cis-trans isomerase, FKBP-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0001708 cell fate specification IMP
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010468 regulation of gene expression IGI
 biological_processGO:0021904 dorsal/ventral neural tube patterning IMP
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0030510 regulation of BMP signaling pathway IGI
 biological_processGO:0030513 positive regulation of BMP signaling pathway IMP
 biological_processGO:0035264 multicellular organism growth IGI
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0061077 chaperone-mediated protein folding IBA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005740 mitochondrial envelope IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IDA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005528 FK506 binding IBA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0097718 disordered domain specific binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
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Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0000576 clubbed feet "congenital deformation of the feet; foot is plantarflexed, inverted and adducted" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fkbp8Gt(OST287985)Lex/Fkbp8Gt(OST287985)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0000932 absent notochord "missing axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fkbp8Gt(OST287985)Lex/Fkbp8Gt(OST287985)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0000962 disorganized dorsal root ganglia "loss of segmentation pattern of DRGs; loss of regular spacing " [J:62022, J:62023]
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Allelic Composition: Fkbp8Gt(OST287985)Lex/Fkbp8Gt(OST287985)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000964 small dorsal root ganglia "reduced size of the dorsal root ganglia" [J:17123]
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Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
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Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0001704 abnormal dorsal-ventral axis patterning "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

Allelic Composition: Fkbp8Gt(OST287985)Lex/Fkbp8Gt(OST287985)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(Fabp4-cre/ERT2)1Ipc/0
Genetic Background: involves: C57BL/6

Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

Allelic Composition: Fkbp8Gt(OST287985)Lex/Fkbp8Gt(OST287985)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0002809 enlarged spinal cord size "larger appearance of the spinal cord" [J:83935]
Show

Allelic Composition: Fkbp8Gt(OST287985)Lex/Fkbp8Gt(OST287985)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Fkbp8Gt(OST287985)Lex/Fkbp8Gt(OST287985)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0004599 abnormal vertebral arch morphology "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fkbp8Gt(OST287985)Lex/Fkbp8Gt(OST287985)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004704 short vertebral column "decreased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fkbp8Gt(OST287985)Lex/Fkbp8Gt(OST287985)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005226 abnormal vertebral arch development "anomalous formation of the posterior projection from the body of a vertebra that encloses the vertebral foramen " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fkbp8Gt(OST287985)Lex/Fkbp8Gt(OST287985)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ror2tm1Ymi/Ror2tm1Ymi
Genetic Background: involves: 129P2/OlaHsd

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fkbp8Gt(OST287985)Lex/Fkbp8Gt(OST287985)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
Show

Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Fkbp8tm1Kei/Fkbp8tm1Kei
Genetic Background: involves: 129 * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili
Genetic Background: Not Specified

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
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Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0012505 increased neural tube apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Fkbp8Gt(OST287985)Lex/Fkbp8Gt(OST287985)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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