ENSMUSG00000019470


Mus musculus

Features
Gene ID: ENSMUSG00000019470
  
Biological name :Xab2
  
Synonyms : Q9DCD2 / Xab2 / XPA binding protein 2
  
Possible biological names infered from orthology : Q9HCS7
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A1.1
Gene start: 3608421
Gene end: 3621316
  
Corresponding Affymetrix probe sets: 10576728 (MoGene1.0st)   1436886_x_at (Mouse Genome 430 2.0 Array)   1437281_x_at (Mouse Genome 430 2.0 Array)   1448278_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124237
Ensembl peptide - ENSMUSP00000019614
Ensembl peptide - ENSMUSP00000124202
NCBI entrez gene - 67439     See in Manteia.
MGI - MGI:1914689
RefSeq - XM_006508864
RefSeq - XM_011242072
RefSeq - NM_026156
RefSeq Peptide - NP_080432
swissprot - Q9DCD2
swissprot - F6TM12
swissprot - E0CYF8
Ensembl - ENSMUSG00000019470
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xab2ENSDARG00000007092Danio rerio
 XAB2ENSG00000076924Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003107  HAT (Half-A-TPR) repeat
 IPR003661  Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000160 phosphorelay signal transduction system IEA
 biological_processGO:0000349 generation of catalytic spliceosome for first transesterification step IBA
 biological_processGO:0000398 mRNA splicing, via spliceosome IEA
 biological_processGO:0001824 blastocyst development IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair IEA
 biological_processGO:0006351 transcription, DNA-templated ISO
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 cellular_componentGO:0000974 Prp19 complex IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0071007 U2-type catalytic step 2 spliceosome IEA
 cellular_componentGO:0071010 prespliceosome IBA
 cellular_componentGO:0071012 catalytic step 1 spliceosome IBA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IEA
 cellular_componentGO:0071014 post-mRNA release spliceosomal complex IBA
 molecular_functionGO:0000155 phosphorelay sensor kinase activity IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0009781 abnormal preimplantation embryo development "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdh1tm3.2Kem/Cdh1tm3.2Kem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Xab2tm2Tnka/Xab2tm2Tnka
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Cdh1tm3.2Kem/Cdh1tm3.2Kem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Xab2tm2Tnka/Xab2tm2Tnka
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0012111 failure of morula compaction "inability to initiate or maintain the first cell differentiation event in mammalian development, occurring at the late eight-cell stage in the mouse, whereby cells on the outer part of the morula become flattened and bound tightly together with the formation of desmosomes and gap junctions, becoming nearly indistinguishable" [MGI:anna]
Show

Allelic Composition: Cdh1tm3.2Kem/Cdh1tm3.2Kem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Xab2tm2Tnka/Xab2tm2Tnka
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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