ENSMUSG00000019489


Mus musculus

Features
Gene ID: ENSMUSG00000019489
  
Biological name :Cd70
  
Synonyms : Cd70 / CD70 antigen / O55237
  
Possible biological names infered from orthology : CD70 molecule / P32970
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: D
Gene start: 57145997
Gene end: 57149777
  
Corresponding Affymetrix probe sets: 10452301 (MoGene1.0st)   1449926_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019633
NCBI entrez gene - 21948     See in Manteia.
MGI - MGI:1195273
RefSeq - NM_011617
RefSeq Peptide - NP_035747
swissprot - O55237
swissprot - Q05A52
Ensembl - ENSMUSG00000019489
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD70ENSG00000125726Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0008283 cell proliferation IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome IBA
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc27a4pskn/Slc27a4pskn
Genetic Background: involves: FVB

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc27a4pskn/Slc27a4pskn
Genetic Background: involves: FVB

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc27a4pskn/Slc27a4pskn
Genetic Background: involves: FVB

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc27a4pskn/Slc27a4pskn
Genetic Background: involves: FVB

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc27a4pskn/Slc27a4pskn
Genetic Background: involves: FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030336 Cd27 / P41272 / CD27 antigen / P26842* / CD27 molecule*  / reaction / complex
 ENSMUSG00000019489 Cd70 / O55237 / CD70 antigen / P32970* / CD70 molecule*  / complex






 

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