ENSMUSG00000019494


Mus musculus

Features
Gene ID: ENSMUSG00000019494
  
Biological name :Cops6
  
Synonyms : COP9 signalosome complex subunit 6 / Cops6 / O88545
  
Possible biological names infered from orthology : COP9 signalosome subunit 6 / Q7L5N1
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 138161071
Gene end: 138164646
  
Corresponding Affymetrix probe sets: 10526743 (MoGene1.0st)   1451366_at (Mouse Genome 430 2.0 Array)   1451367_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121554
Ensembl peptide - ENSMUSP00000019638
Ensembl peptide - ENSMUSP00000106576
NCBI entrez gene - 26893     See in Manteia.
MGI - MGI:1349439
RefSeq - NM_012002
RefSeq Peptide - NP_036132
swissprot - Q3UIT2
swissprot - D3Z0F5
swissprot - F6QK86
swissprot - O88545
Ensembl - ENSMUSG00000019494
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 COPS6ENSG00000168090Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eif3f / Q9DCH4 / Eukaryotic translation initiation factor 3 subunit F / O00303*ENSMUSG0000003102922
Psmd7 / P26516 / proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 / P51665* / proteasome 26S subunit, non-ATPase 7*ENSMUSG0000003906721


Protein motifs (from Interpro)
Interpro ID Name
 IPR000555  JAB1/MPN/MOV34 metalloenzyme domain
 IPR024969  Rpn11/EIF3F, C-terminal
 IPR033859  COP9 signalosome subunit 6
 IPR037518  MPN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000338 protein deneddylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0008180 COP9 signalosome IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
Show

Allelic Composition: Cops6Gt(RRI087)Byg/Cops6Gt(RRI087)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Cops6Gt(RRI087)Byg/Cops6Gt(RRI087)Byg,Trp53tm1Glo/Trp53tm1Glo
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Cops6Gt(RRI087)Byg/Cops6Gt(RRI087)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cops6Gt(RRI087)Byg/Cops6Gt(RRI087)Byg,Trp53tm1Glo/Trp53tm1Glo
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0004500 increased incidence of ionizing radiation-induced tumors "higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004503 decreased incidence of ionizing radiation-induced tumors "lower than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cops6Gt(RRI087)Byg/Cops6Gt(RRI087)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cops6Gt(RRI087)Byg/Cops6Gt(RRI087)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cops6Gt(RRI087)Byg/Cops6Gt(RRI087)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cops6Gt(RRI087)Byg/Cops6Gt(RRI087)Byg,Trp53tm1Glo/Trp53tm1Glo
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Cks2TgTn(sb-cHS4,Tyr)2525F-2Ove/Cks2TgTn(sb-cHS4,Tyr)2525F-2Ove
Genetic Background: FVB/N-Cks2TgTn(sb-cHS4,Tyr)2525F-2Ove

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cul4atm1.1Pra/Cul4atm1.1Pra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6NTac * DBA

Allelic Composition: Cops6Gt(RRI087)Byg/Cops6Gt(RRI087)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0011107 partial embryonic lethality before turning of embryo "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Cul4atm1.1Pra/Cul4atm1.1Pra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6NTac * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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