ENSMUSG00000019795


Mus musculus

Features
Gene ID: ENSMUSG00000019795
  
Biological name :Pcmt1
  
Synonyms : Pcmt1 / protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
  
Possible biological names infered from orthology : P22061 / protein-L-isoaspartate (D-aspartate) O-methyltransferase
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A1
Gene start: 7629373
Gene end: 7681136
  
Corresponding Affymetrix probe sets: 10367708 (MoGene1.0st)   1422665_a_at (Mouse Genome 430 2.0 Array)   1431085_a_at (Mouse Genome 430 2.0 Array)   1431086_s_at (Mouse Genome 430 2.0 Array)   1456604_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124135
Ensembl peptide - ENSMUSP00000124100
Ensembl peptide - ENSMUSP00000124246
Ensembl peptide - ENSMUSP00000125144
Ensembl peptide - ENSMUSP00000124932
Ensembl peptide - ENSMUSP00000123758
Ensembl peptide - ENSMUSP00000123866
NCBI entrez gene - 18537     See in Manteia.
MGI - MGI:97502
RefSeq - XM_017313837
RefSeq - XM_006512594
RefSeq - XM_006512595
RefSeq - XM_011243140
RefSeq - XM_011243141
RefSeq - XM_017313832
RefSeq - XM_017313833
RefSeq - XM_017313834
RefSeq - XM_017313835
RefSeq - XM_017313836
RefSeq - NM_008786
RefSeq - XM_006512588
RefSeq - XM_006512589
RefSeq - XM_006512590
RefSeq Peptide - NP_001334157
RefSeq Peptide - NP_032812
swissprot - F6TXE3
swissprot - F6V9F1
swissprot - E9PWE0
swissprot - E0CYJ5
swissprot - E0CYF2
swissprot - F7D432
swissprot - E0CYV0
Ensembl - ENSMUSG00000019795
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcmtENSDARG00000015201Danio rerio
 PCMT1ENSGALG00000012388Gallus gallus
 PCMT1ENSG00000120265Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000682  Protein-L-isoaspartate(D-aspartate) O-methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process IEA
 biological_processGO:0006479 protein methylation IEA
 biological_processGO:0032259 methylation IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Protein repair


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: ApcMin/Apc+,EgfrWa5/Egfr+
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: ApcMin/Apc+,EgfrWa5/Egfr+
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,EgfrWa5/Egfr+
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: ApcMin/Apc+,EgfrWa5/Egfr+
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

 MP:0003996 clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by unilateral or bilateral rhythmic jerking movements of the arms and legs caused by alternating contraction and relaxation of muscle" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,EgfrWa5/Egfr+
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005571 decreased lactate dehydrogenase level "less than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,EgfrWa5/Egfr+
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010091 decreased circulating creatine kinase level "a reduction in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011891 decreased circulating ferritin level "reduced concentration in the blood of ferritin, a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion; some ferritin is also found in the blood and is measured in tests for overall iron levels, anemia and chronic diseases" [MGI:csmith]
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Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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