ENSMUSG00000019852


Mus musculus

Features
Gene ID: ENSMUSG00000019852
  
Biological name :Arfgef3
  
Synonyms : Arfgef3 / Brefeldin A-inhibited guanine nucleotide-exchange protein 3 / Q3UGY8
  
Possible biological names infered from orthology : ARFGEF family member 3 / Q5TH69
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A3
Gene start: 18581839
Gene end: 18743949
  
Corresponding Affymetrix probe sets: 10368101 (MoGene1.0st)   1435050_at (Mouse Genome 430 2.0 Array)   1455995_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000149210
Ensembl peptide - ENSMUSP00000019999
NCBI entrez gene - 215821     See in Manteia.
MGI - MGI:106387
RefSeq - NM_001033258
RefSeq Peptide - NP_001028430
swissprot - A0A1N9M5I8
swissprot - Q3UGY8
Ensembl - ENSMUSG00000019852
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arfgef3ENSDARG00000077656Danio rerio
 ARFGEF3ENSGALG00000013846Gallus gallus
 Q5TH69ENSG00000112379Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000904  Sec7 domain
 IPR011989  Armadillo-like helical
 IPR015403  Sec7, C-terminal
 IPR016024  Armadillo-type fold
 IPR023394  Sec7, C-terminal domain superfamily
 IPR032629  Mon2, dimerisation and cyclophilin-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010923 negative regulation of phosphatase activity IEA
 biological_processGO:0032012 regulation of ARF protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005086 ARF guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005488 binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gjb2tm1Kkam/Gjb2tm1Kkam,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gjb2tm1Kkam/Gjb2tm1Kkam,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gjb2tm1Kkam/Gjb2tm1Kkam,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Gjb2tm1Kkam/Gjb2tm1Kkam,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gjb2tm1Kkam/Gjb2tm1Kkam,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gjb2tm1Kkam/Gjb2tm1Kkam,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gjb2tm1Kkam/Gjb2tm1Kkam,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
Show

Allelic Composition: Gjb2tm1Kkam/Gjb2tm1Kkam,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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