ENSMUSG00000020098


Mus musculus

Features
Gene ID: ENSMUSG00000020098
  
Biological name :Pcbd1
  
Synonyms : P61458 / Pcbd1 / Pterin-4-alpha-carbinolamine dehydratase
  
Possible biological names infered from orthology : P61457 / pterin-4 alpha-carbinolamine dehydratase 1
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B4
Gene start: 61089331
Gene end: 61094324
  
Corresponding Affymetrix probe sets: 10363455 (MoGene1.0st)   1418713_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151542
Ensembl peptide - ENSMUSP00000020298
NCBI entrez gene - 13180     See in Manteia.
MGI - MGI:94873
RefSeq - NM_025273
RefSeq Peptide - NP_079549
swissprot - A0A1W2P7A4
swissprot - P61458
Ensembl - ENSMUSG00000020098
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcbd1ENSDARG00000031981Danio rerio
 PCBD1ENSGALG00000027835Gallus gallus
 PCBD1ENSG00000166228Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pcbd2 / Q9CZL5 / Pterin-4-alpha-carbinolamine dehydratase 2 / Q9H0N5*ENSMUSG0000002149664


Protein motifs (from Interpro)
Interpro ID Name
 IPR001533  Pterin 4 alpha carbinolamine dehydratase
 IPR036428  Pterin 4 alpha carbinolamine dehydratase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006558 L-phenylalanine metabolic process IEA
 biological_processGO:0006729 tetrahydrobiopterin biosynthetic process IEA
 biological_processGO:0043496 regulation of protein homodimerization activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0051289 protein homotetramerization IPI
 biological_processGO:0051291 protein heterooligomerization IPI
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0004505 phenylalanine 4-monooxygenase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity ISO
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Phenylalanine and tyrosine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: TnfM1Btlr/Tnf+
Genetic Background: C57BL/6J-TnfM1Btlr

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: TnfM1Btlr/Tnf+
Genetic Background: C57BL/6J-TnfM1Btlr

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: TnfM1Btlr/Tnf+
Genetic Background: C57BL/6J-TnfM1Btlr

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: TnfM1Btlr/Tnf+
Genetic Background: C57BL/6J-TnfM1Btlr

 MP:0002893 ketoaciduria "excretion of urine having an elevated concentration of keto acids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: TnfM1Btlr/Tnf+
Genetic Background: C57BL/6J-TnfM1Btlr

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: TnfM1Btlr/Tnf+
Genetic Background: C57BL/6J-TnfM1Btlr

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: TnfM1Btlr/Tnf+
Genetic Background: C57BL/6J-TnfM1Btlr

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: TnfM1Btlr/Tnf+
Genetic Background: C57BL/6J-TnfM1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020098 Pcbd1 / P61458 / Pterin-4-alpha-carbinolamine dehydratase / P61457* / pterin-4 alpha-carbinolamine dehydratase 1*  / complex






 

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