ENSMUSG00000020108


Mus musculus

Features
Gene ID: ENSMUSG00000020108
  
Biological name :Ddit4
  
Synonyms : Ddit4 / DNA damage-inducible transcript 4 protein / Q9D3F7
  
Possible biological names infered from orthology : DNA damage inducible transcript 4 / Q9NX09
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B4
Gene start: 59949669
Gene end: 59951834
  
Corresponding Affymetrix probe sets: 10369290 (MoGene1.0st)   1428306_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020308
NCBI entrez gene - 74747     See in Manteia.
MGI - MGI:1921997
RefSeq - NM_029083
RefSeq Peptide - NP_083359
swissprot - B7ZNP9
swissprot - Q9D3F7
Ensembl - ENSMUSG00000020108
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddit4ENSDARG00000037618Danio rerio
 DDIT4ENSGALG00000041459Gallus gallus
 DDIT4ENSG00000168209Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ddit4l / Q8VHZ5 / DNA damage-inducible transcript 4-like protein / Q96D03* / DNA damage inducible transcript 4 like*ENSMUSG0000004681826


Protein motifs (from Interpro)
Interpro ID Name
 IPR012918  RTP801-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001764 neuron migration ISS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007420 brain development ISS
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation ISS
 biological_processGO:0030182 neuron differentiation ISS
 biological_processGO:0032007 negative regulation of TOR signaling ISO
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation ISS
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
 biological_processGO:0045820 negative regulation of glycolytic process IMP
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway ISS
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0071549 cellular response to dexamethasone stimulus IDA
 biological_processGO:0072593 reactive oxygen species metabolic process IMP
 biological_processGO:1901216 positive regulation of neuron death ISS
 biological_processGO:1902532 negative regulation of intracellular signal transduction ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0071889 14-3-3 protein binding IDA


Pathways (from Reactome)
Pathway description
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgl2tm1Pam/Fgl2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Clcn5tm1Gug/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010050 hypermyelination "anomaly in the process by which myelin sheaths are formed and maintained around neurons resulting in increased myelin formation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clcn5tm1Gug/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0030006 decreased retinal apoptosis "decrease in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Clcn5tm1Gug/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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