ENSMUSG00000020150


Mus musculus

Features
Gene ID: ENSMUSG00000020150
  
Biological name :Gamt
  
Synonyms : Gamt / Mus musculus guanidinoacetate methyltransferase (Gamt), transcript variant 2, mRNA. / O35969
  
Possible biological names infered from orthology : guanidinoacetate N-methyltransferase / Q14353
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 80258151
Gene end: 80261012
  
Corresponding Affymetrix probe sets: 10370766 (MoGene1.0st)   1422558_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020359
Ensembl peptide - ENSMUSP00000101002
NCBI entrez gene - 14431     See in Manteia.
MGI - MGI:1098221
RefSeq - XM_006513222
RefSeq - NM_001347119
RefSeq - NM_010255
RefSeq - XM_006513221
RefSeq Peptide - NP_001334048
RefSeq Peptide - NP_034385
swissprot - O35969
Ensembl - ENSMUSG00000020150
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gamtENSDARG00000070844Danio rerio
 GAMTENSGALG00000040182Gallus gallus
 GAMTENSG00000130005Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR016550  Guanidinoacetate N-methyltransferase
 IPR026480  Arginine N-methyltransferase 2-like domain
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006601 creatine biosynthetic process ISO
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0040014 regulation of multicellular organism growth IMP
 biological_processGO:0046498 S-adenosylhomocysteine metabolic process IBA
 biological_processGO:0046500 S-adenosylmethionine metabolic process IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030731 guanidinoacetate N-methyltransferase activity ISO


Pathways (from Reactome)
Pathway description
Creatine metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000679 increased percent water in carcass "more than the normal total amount of water retained in the body measured post mortem" [il:Ira Lu, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0001506 limp posture "lack of rigidity of the carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0005328 abnormal circulating creatinine level "anomalous blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0011468 abnormal urine amino acid level "any anomaly in the amount in the urine of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group" [CHEBI:33709, MGI:csmith]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr