Manteia - Molecule gene

ENSMUSG00000020153

Mus musculus

Features

Gene ID:	ENSMUSG00000020153

Biological name :	Ndufs7

Synonyms :	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial / Ndufs7 / Q9DC70

Possible biological names infered from orthology :	NADH:ubiquinone oxidoreductase core subunit S7 / O75251

Species:	Mus musculus

Chr. number:	10
Strand:	1
Band:	C1
Gene start:	80249121
Gene end:	80256794

Corresponding Affymetrix probe sets:	10364744 (MoGene1.0st) 1424313_a_at (Mouse Genome 430 2.0 Array) 1451312_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000020361 Ensembl peptide - ENSMUSP00000101003 NCBI entrez gene - 75406 See in Manteia. MGI - MGI:1922656 RefSeq - XM_006514270 RefSeq - NM_029272 RefSeq Peptide - NP_083548 swissprot - Q9DC70 Ensembl - ENSMUSG00000020153

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ndufs7	ENSDARG00000074552	Danio rerio
NDUFS7	ENSGALG00000009703	Gallus gallus
NDUFS7	ENSG00000115286	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR006137	NADH:ubiquinone oxidoreductase-like, 20kDa subunit
IPR006138	NADH-ubiquinone oxidoreductase, 20 Kd subunit
IPR037024	[NiFe]-hydrogenase, small subunit, N-terminal domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	ISS
biological_process	GO:0055114	oxidation-reduction process	IEA
cellular_component	GO:0005739	mitochondrion	IDA
cellular_component	GO:0005743	mitochondrial inner membrane	IDA
cellular_component	GO:0005747	mitochondrial respiratory chain complex I	ISO
cellular_component	GO:0043005	neuron projection	IEA
cellular_component	GO:0043025	neuronal cell body	IEA
cellular_component	GO:0070469	respiratory chain	IEA
cellular_component	GO:0097060	synaptic membrane	IEA
molecular_function	GO:0002020	protease binding	IEA
molecular_function	GO:0003954	NADH dehydrogenase activity	ISO
molecular_function	GO:0008137	NADH dehydrogenase (ubiquinone) activity	IEA
molecular_function	GO:0016491	oxidoreductase activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0048038	quinone binding	IEA
molecular_function	GO:0051536	iron-sulfur cluster binding	IEA
molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	IEA

Pathways (from Reactome)

Pathway description

Respiratory electron transport

Complex I biogenesis

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Kiss1r^{tm1.1(KOMP)Vlcg}/Kiss1r^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Kiss1r^{tm1.1(KOMP)Vlcg}/Ucd
MP:0001697	abnormal embryo size	"anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Kiss1r^{tm1.1(KOMP)Vlcg}/Kiss1r^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Kiss1r^{tm1.1(KOMP)Vlcg}/Ucd Allelic Composition: Ndufs7^{tm1b(EUCOMM)Hmgu}/Ndufs7^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Ndufs7^{tm1b(EUCOMM)Hmgu}/Bay
MP:0001700	abnormal embryo turning	"atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kiss1r^{tm1.1(KOMP)Vlcg}/Kiss1r^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Kiss1r^{tm1.1(KOMP)Vlcg}/Ucd
MP:0001718	abnormal yolk sac	"malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]	Show Allelic Composition: Kiss1r^{tm1.1(KOMP)Vlcg}/Kiss1r^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Kiss1r^{tm1.1(KOMP)Vlcg}/Ucd
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kiss1r^{tm1.1(KOMP)Vlcg}/Kiss1r^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Kiss1r^{tm1.1(KOMP)Vlcg}/Ucd Allelic Composition: Ndufs7^{tm1b(EUCOMM)Hmgu}/Ndufs7^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Ndufs7^{tm1b(EUCOMM)Hmgu}/Bay
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Ndufs7^{tm1b(EUCOMM)Hmgu}/Ndufs7^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Ndufs7^{tm1b(EUCOMM)Hmgu}/Bay
MP:0013292	embryonic lethality prior to organogenesis	"death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]	Show Allelic Composition: Ndufs7^{tm1b(EUCOMM)Hmgu}/Ndufs7^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Ndufs7^{tm1b(EUCOMM)Hmgu}/Bay

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr